April, 2014
No. 99 (4)

Editorials

Editorials & Perspectives

Review Articles

Why methylation is not a marker predictive of response to hypomethylating agents

Maria Teresa Voso, Valeria Santini, Emiliano Fabiani, Luana Fianchi, Marianna Criscuolo, Giulia Falconi, Francesco Guidi, Stefan Hohaus, Giuseppe Leone

https://doi.org/10.3324/haematol.2013.099549

Primary thrombocytosis in children

Nicole Kucine, Katherine M. Chastain, Michelle B. Mahler, James B. Bussel

https://doi.org/10.3324/haematol.2013.092684

Articles

In vivo evidence for an instructive role of fms-like tyrosine kinase-3 (FLT3) ligand in hematopoietic development

Panagiotis Tsapogas, Lee Kim Swee, Anja Nusser, Natko Nuber, Matthias Kreuzaler, Giuseppina Capoferri, Hannie Rolink, Rhodri Ceredig, Antonius Rolink

https://doi.org/10.3324/haematol.2013.089482

The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease

Sofie Singbrant, Meaghan Wall, Jennifer Moody, Göran Karlsson, Alistair M. Chalk, Brian Liddicoat, Megan R. Russell, Carl R. Walkley, Stefan Karlsson

https://doi.org/10.3324/haematol.2013.093971

Comparison of horse and rabbit antithymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood

Ayami Yoshimi, Marry M. van den Heuvel-Eibrink, Irith Baumann, Stephan Schwarz, Ingrid Simonitsch-Klupp, Pascale de Paepe, Vit Campr, Gitte Birk Kerndrup, Maureen O’Sullivan, Rita Devito, Roos Leguit, Miguel Hernandez, Michael Dworzak, Barbara de Moerloose, Jan Starý, Henrik Hasle, Owen P. Smith, Marco Zecca, Albert Catala, Markus Schmugge, Franco Locatelli, Monika Führer, Alexandra Fischer, Anne Guderle, Peter Nöllke, Brigitte Strahm, Charlotte M. Niemeyer

https://doi.org/10.3324/haematol.2013.095786

Long-term outcome after immunosuppressive therapy with horse or rabbit antithymocyte globulin and cyclosporine for severe aplastic anemia in children

Dae Chul Jeong, Nack Gyun Chung, Bin Cho, Yao Zou, Min Ruan, Yoshiyuki Takahashi, Hideki Muramatsu, Akira Ohara, Yoshiyuki Kosaka, Wenyu Yang, Hack Ki Kim, Xiaofan Zhu, Seiji Kojima

https://doi.org/10.3324/haematol.2013.089268

A phase II trial of sequential ribonucleotide reductase inhibition in aggressive myeloproliferative neoplasms

Joshua F. Zeidner, Judith E. Karp, Amanda L. Blackford, B. Douglas Smith, Ivana Gojo, Steven D. Gore, Mark J. Levis, Hetty E. Carraway, Jacqueline M. Greer, S. Percy Ivy, Keith W. Pratz, Michael A. McDevitt

https://doi.org/10.3324/haematol.2013.097246

Combination therapy of hydroxycarbamide with anagrelide in patients with essential thrombocythemia in the evaluation of Xagrid® efficacy and long-term safety study

Luigi Gugliotta, Carlos Besses, Martin Griesshammer, Claire Harrison, Jean-Jacques Kiladjian, Ruth Coll, Jonathan Smith, Brihad Abhyankar, Gunnar Birgegård

https://doi.org/10.3324/haematol.2012.083097

CHK1 and WEE1 inhibition combine synergistically to enhance therapeutic efficacy in acute myeloid leukemia ex vivo

Leena Chaudhuri, Nicole D. Vincelette, Brian D. Koh, Ryan M. Naylor, Karen S. Flatten, Kevin L. Peterson, Amanda McNally, Ivana Gojo, Judith E. Karp, Ruben A Mesa, Lisa O. Sproat, James M. Bogenberger, Scott H. Kaufmann, Raoul Tibes

https://doi.org/10.3324/haematol.2013.093187

The gene signature in CCAAT-enhancer-binding protein α dysfunctional acute myeloid leukemia predicts responsiveness to histone deacetylase inhibitors

Adam Liss, Chia-Huey Ooi, Polina Zjablovskaja, Touati Benoukraf, Hanna S. Radomska, Chen Ju, Mengchu Wu, Martin Balastik, Ruud Delwel, Tomas Brdicka, Patrick Tan, Daniel G. Tenen, Meritxell Alberich-Jorda

https://doi.org/10.3324/haematol.2013.093278

Copy number genome alterations are associated with treatment response and outcome in relapsed childhood ETV6/RUNX1-positive acute lymphoblastic leukemia

Almut Bokemeyer, Cornelia Eckert, Franziska Meyr, Gabriele Koerner, Arend von Stackelberg, Reinhard Ullmann, Seval Türkmen, Günter Henze, Karl Seeger

https://doi.org/10.3324/haematol.2012.072470

The reliability of immunohistochemical analysis of the tumor microenvironment in follicular lymphoma: a validation study from the Lunenburg Lymphoma Biomarker Consortium

Birgitta Sander, Daphne de Jong, Andreas Rosenwald, Wanling Xie, Olga Balagué, Maria Calaminici, Joaquim Carreras, Philippe Gaulard, John Gribben, Anton Hagenbeek, Marie José Kersten, Thierry Jo Molina, Abigail Lee, Santiago Montes-Moreno, German Ott, John Raemaekers, Gilles Salles, Laurie Sehn, Christoph Thorns, Björn E. Wahlin, Randy D. Gascoyne, Edie Weller

https://doi.org/10.3324/haematol.2013.095257

Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma

Sietse M. Aukema, Markus Kreuz, Christian W Kohler, Maciej Rosolowski, Dirk Hasenclever, Michael Hummel, Ralf Küppers, Dido Lenze, German Ott, Christiane Pott, Julia Richter, Andreas Rosenwald, Monika Szczepanowski, Carsten Schwaenen, Harald Stein, Heiko Trautmann, Swen Wessendorf, Lorenz Trümper, Markus Loeffler, Rainer Spang, Philip M. Kluin, Wolfram Klapper, Reiner Siebert

https://doi.org/10.3324/haematol.2013.091827

ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial

Matthew J.J. Rose-Zerilli, Jade Forster, Helen Parker, Anton Parker, Ana E. Rodríguez, Tracy Chaplin, Anne Gardiner, Andrew J. Steele, Andrew Collins, Bryan D. Young, Anna Skowronska, Daniel Catovsky, Tatjana Stankovic, David G. Oscier, Jonathan C. Strefford

https://doi.org/10.3324/haematol.2013.098574

Oral melphalan and dexamethasone grants extended survival with minimal toxicity in AL amyloidosis: long-term results of a risk-adapted approach

Giovanni Palladini, Paolo Milani, Andrea Foli, Laura Obici, Francesca Lavatelli, Mario Nuvolone, Riccardo Caccialanza, Stefano Perlini, Giampaolo Merlini

https://doi.org/10.3324/haematol.2013.095463

A Good Manufacturing Practice procedure to engineer donor virus-specific T cells into potent anti-leukemic effector cells

Marleen M. van Loenen, Renate de Boer, Ellis van Liempt, Pauline Meij, Inge Jedema, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk

https://doi.org/10.3324/haematol.2013.093690

The importance of calcium in the regulation of megakaryocyte function

Christian Andrea Di Buduo, Francesco Moccia, Monica Battiston, Luigi De Marco, Mario Mazzucato, Remigio Moratti, Franco Tanzi, Alessandra Balduini

https://doi.org/10.3324/haematol.2013.096859

Persistence of circulating ADAMTS13-specific immune complexes in patients with acquired thrombotic thrombocytopenic purpura

Silvia Ferrari, Kristina Palavra, Bernadette Gruber, Johanna A. Kremer Hovinga, Paul Knöbl, Claudine Caron, Caroline Cromwell, Louis Aledort, Barbara Plaimauer, Peter L. Turecek, Hanspeter Rottensteiner, Friedrich Scheiflinger

https://doi.org/10.3324/haematol.2013.094151

Patient- versus physician-reporting of symptoms and health status in chronic myeloid leukemia

Fabio Efficace, Gianantonio Rosti, Neil Aaronson, Francesco Cottone, Emanuele Angelucci, Stefano Molica, Marco Vignetti, Franco Mandelli, Michele Baccarani

https://doi.org/10.3324/haematol.2013.093724

Online Only Articles

A novel distal upstream hypoxia response element regulating oxygen-dependent erythropoietin gene expression

Federica Storti, Sara Santambrogio, Lisa M. Crowther, Teresa Otto, Irene Abreu-Rodríguez, Muriel Kaufmann, Cheng-Jun Hu, Christof Dame, Joachim Fandrey, Roland H. Wenger, David Hoogewijs

https://doi.org/10.3324/haematol.2013.102707

Molecular characterization and clinical course of MLL-ACTN4 rearrangement in therapy-related hematologic malignancies

John Jeongseok Yang, Tae Sung Park, Seung-Tae Lee, Ja-Young Seo, Seung Hwan Oh, Eun Hae Cho, Thomas Burmeister, Wolf-Dieter Ludwig, Claus Meyer, Rolf Marschalek, Hee-Jin Kim, Sun-Hee Kim

https://doi.org/10.3324/haematol.2013.102798

The International Prognostic Scoring System does not accurately discriminate different risk categories in patients with post-essential thrombocythemia and post-polycythemia vera myelofibrosis

Juan-Carlos Hernández-Boluda, Arturo Pereira, Montse Gómez, Concepción Boqué, Francisca Ferrer-Marín, José-María Raya, Valentín García-Gutiérrez, Ana Kerguelen, Blanca Xicoy, Pere Barba, Jesús Martínez, Elisa Luño, Alberto Alvarez-Larrán, Joaquín Martínez-López, Elisa Arbelo, Carles Besses

https://doi.org/10.3324/haematol.2013.101733

Obituary