November, 2013
No. 98 (11)

Editorials

Review Articles

Articles

Mesenchymal stromal cells from patients with myelodyplastic syndrome display distinct functional alterations that are modulated by lenalidomide

Ruben A. Ferrer, Manja Wobus, Catrin List, Rebekka Wehner, Claudia Schönefeldt, Barbara Brocard, Brigitte Mohr, Martina Rauner, Marc Schmitz, Maik Stiehler, Gerhard Ehninger, Lorenz C. Hofbauer, Martin Bornhäuser, Uwe Platzbecker

https://doi.org/10.3324/haematol.2013.083972

Chronic Myeloid Leukemia

Assessment at 6 months may be warranted for patients with chronic myeloid leukemia with no major cytogenetic response at 3 months

Aziz Nazha, Hagop Kantarjian, Preetesh Jain, Carlos Romo, Elias Jabbour, Alfonso Quintas-Cardama, Raja Luthra, Lynne Abruzzo, Gautam Borthakur, Farhad Ravandi, Sherry Pierce, Susan O’Brien, Jorge Cortes

https://doi.org/10.3324/haematol.2013.090282

Comprehensive whole-genome sequencing of an early-stage primary myelofibrosis patient defines low mutational burden and non-recurrent candidate genes

Jason D. Merker, Krishna M. Roskin, Dana Ng, Cuiping Pan, Dianna G. Fisk, Jasmine J. King, Ramona Hoh, Michael Stadler, Lawrence M. Okumoto, Parveen Abidi, Rhonda Hewitt, Carol D. Jones, Linda Gojenola, Michael J. Clark, Bing Zhang, Athena M. Cherry, Tracy I. George, Michael Snyder, Scott D. Boyd, James L. Zehnder, Andrew Z. Fire, Jason Gotlib

https://doi.org/10.3324/haematol.2013.092379

Pediatric Acute Lymphoblastic Leukemia: Efficacy and safety of recombinant E. coli-asparaginase in infants (less than one year of age) with acute lymphoblastic leukemia

Inge van der Sluis, Anja Möricke, Gabriele Escherich, Arend von Stackelberg, Wolfgang Holter, Thomas Klingebiel, Christian Flotho, Sabine Legien, Wim Tissing, Marc Bierings, Cecile Guimbal-Schmolck, Uwe Pichlmeier, Hans-Jürgen Kühnel, Rob Pieters

https://doi.org/10.3324/haematol.2013.090563

Clinico-biological features of 5202 patients with acute lymphoblastic leukemia enrolled in the Italian AIEOP and GIMEMA protocols and stratified in age cohorts

Sabina Chiaretti, Antonella Vitale, Gianni Cazzaniga, Sonia Maria Orlando, Daniela Silvestri, Paola Fazi, Maria Grazia Valsecchi, Loredana Elia, Anna Maria Testi, Francesca Mancini, Valentino Conter, Geertruy te Kronnie, Felicetto Ferrara, Francesco Di Raimondo, Alessandra Tedeschi, Giuseppe Fioritoni, Francesco Fabbiano, Giovanna Meloni, Giorgina Specchia, Giovanni Pizzolo, Franco Mandelli, Anna Guarini, Giuseppe Basso, Andrea Biondi, Robin Foà

https://doi.org/10.3324/haematol.2012.080432

The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest

Raouf Ben Abdelali, Vahid Asnafi, Arnaud Petit, Jean-Baptiste Micol, Céline Callens, Patrick Villarese, Eric Delabesse, Oumedaly Reman, Stephane Lepretre, Jean-Yves Cahn, Gaelle Guillerm, Céline Berthon, Claude Gardin, Bernadette Corront, Thibaut Leguay, Marie-Christine Béné, Norbert Ifrah, Guy Leverger, Hervé Dombret, Elizabeth Macintyre

https://doi.org/10.3324/haematol.2013.086082

High cure rates in Burkitt lymphoma and leukemia: a Northern Italy Leukemia Group study of the German short intensive rituximab-chemotherapy program

Tamara Intermesoli, Alessandro Rambaldi, Giuseppe Rossi, Federica Delaini, Claudio Romani, Enrico Maria Pogliani, Chiara Pagani, Emanuele Angelucci, Elisabetta Terruzzi, Alessandro Levis, Vincenzo Cassibba, Daniele Mattei, Giacomo Gianfaldoni, Anna Maria Scattolin, Eros Di Bona, Elena Oldani, Margherita Parolini, Nicola Gökbuget, Renato Bassan

https://doi.org/10.3324/haematol.2013.086827

Rituximab plus gemcitabine and oxaliplatin in patients with refractory/relapsed diffuse large B-cell lymphoma who are not candidates for high-dose therapy. A phase II Lymphoma Study Association trial

Nicolas Mounier, Taoufik El Gnaoui, Hervé Tilly, Danièle Canioni, Catherine Sebban, René-Olivier Casasnovas, Richard Delarue, Anne Sonet, Pauline Beaussart, Tony Petrella, Sylvie Castaigne, Serge Bologna, Gilles Salles, Alain Rahmouni, Philippe Gaulard, Corinne Haioun

https://doi.org/10.3324/haematol.2013.090597

Lenalidomide plus cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab is safe and effective in untreated, elderly patients with diffuse large B-cell lymphoma: a phase I study by the Fondazione Italiana Linfomi

Annalisa Chiappella, Alessandra Tucci, Alessia Castellino, Vincenzo Pavone, Ileana Baldi, Angelo Michele Carella, Lorella Orsucci, Manuela Zanni, Flavia Salvi, Anna Marina Liberati, Gianluca Gaidano, Chiara Bottelli, Bernardo Rossini, Sonia Perticone, Pasqualina De Masi, Marco Ladetto, Giovannino Ciccone, Antonio Palumbo, Giuseppe Rossi, Umberto Vitolo

https://doi.org/10.3324/haematol.2013.085134

The phosphatidylinositol-3-kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis in chronic lymphocytic leukemia cells

Laia Rosich, Ifigènia Saborit-Villarroya, Mónica López-Guerra, Sílvia Xargay-Torrent, Arnau Montraveta, Marta Aymerich, Neus Villamor, Elias Campo, Patricia Pérez-Galán, Gaël Roué, Dolors Colomer

https://doi.org/10.3324/haematol.2013.088849

STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model

Lucile Couronné, Laurianne Scourzic, Camilla Pilati, Véronique Della Valle, Yannis Duffourd, Eric Solary, William Vainchenker, Jean-Philippe Merlio, Marie Beylot-Barry, Frederik Damm, Marc-Henri Stern, Philippe Gaulard, Laurence Lamant, Eric Delabesse, Hélène Merle-Beral, Florence Nguyen-Khac, Michaëla Fontenay, Hervé Tilly, Christian Bastard, Jessica Zucman-Rossi, Olivier A. Bernard, Thomas Mercher

https://doi.org/10.3324/haematol.2013.085068

Integrated safety profile of single-agent carfilzomib: experience from 526 patients enrolled in 4 phase II clinical studies

David Siegel, Thomas Martin, Ajay Nooka, R. Donald Harvey, Ravi Vij, Ruben Niesvizky, Ashraf Z. Badros, Sundar Jagannath, Leanne McCulloch, Kanya Rajangam, Sagar Lonial

https://doi.org/10.3324/haematol.2013.089334

Stem cell mobilization in HIV seropositive patients with lymphoma

Alessandro Re, Chiara Cattaneo, Cristina Skert, Pascual Balsalobre, Mariagrazia Michieli, Mark Bower, Andrés J. M. Ferreri, Marcus Hentrich, José M. Ribera, Bernardino Allione, Philipp Schommers, Silvia Montoto, Camillo Almici, Pierino Ferremi, Mario Mazzucato, Salvatore Gattillo, Salvatore Casari, Michele Spina, José L. Diez-Martin, Umberto Tirelli, Giuseppe Rossi

https://doi.org/10.3324/haematol.2013.089052

Characteristic phenotypes associated with congenital dyserythropoietic anemia (type II) manifest at different stages of erythropoiesis

Timothy J. Satchwell, Stephanie Pellegrin, Paola Bianchi, Bethan R. Hawley, Alexandra Gampel, Kathryn E. Mordue, Annika Budnik, Elisa Fermo, Wilma Barcellini, David J. Stephens, Emile van den Akker, Ashley M. Toye

https://doi.org/10.3324/haematol.2013.085522

Nucleosomes and neutrophil activation in sickle cell disease painful crisis

Marein Schimmel, Erfan Nur, Bart J. Biemond, Gerard J. van Mierlo, Shabnam Solati, Dees P. Brandjes, Hans-Martin Otten, John-John Schnog, Sacha Zeerleder

https://doi.org/10.3324/haematol.2013.088021

Syngeneic transplantation in aplastic anemia: pre-transplant conditioning and peripheral blood are associated with improved engraftment: an observational study on behalf of the Severe Aplastic Anemia and Pediatric Diseases Working Parties of the European Group for Blood and Marrow Transplantation

Sabine Gerull, Martin Stern, Jane Apperley, Dietrich Beelen, Lorentz Brinch, Donald Bunjes, Andrew Butler, Arnold Ganser, Ardeshir Ghavamzadeh, Mickey B Koh, Mieczyslaw Komarnicki, Nicolaus Kröger, Johan Maertens, Alexei Maschan, Christina Peters, Montserrat Rovira, Henrik Sengeløv, Gerard Socié, Johanna Tischer, Rosi Oneto, Jakob Passweg, Judith Marsh

https://doi.org/10.3324/haematol.2013.091074

Platelet interaction with von Willebrand factor is enhanced by shear-induced clustering of glycoprotein Ibα

Eelo Gitz, Charlotte D. Koopman, Alèkos Giannas, Cornelis A Koekman, Dave J. van den Heuvel, Hans Deckmyn, Jan-Willem N. Akkerman, Hans C. Gerritsen, Rolf T. Urbanus

https://doi.org/10.3324/haematol.2013.087221

Online Only Articles

Thrombospondin-1 inhibits ADAMTS13 activity in sickle cell disease

Enrico M. Novelli, Gregory J. Kato, Mariana E. Hildesheim, Suchitra Barge, Michael P. Meyer, Jay Lozier, Andrea Cortese Hassett, Margaret V. Ragni, Jeffrey S. Isenberg, Mark T. Gladwin

https://doi.org/10.3324/haematol.2013.092635

JAK2V617F allele burden is reduced by busulfan therapy: a new observation using an old drug

Emil T. Kuriakose, Stefani Gjoni, Y. Lynn Wang, Ruth Baumann, Amy V. Jones, Nicholas C. P. Cross, Richard T. Silver

https://doi.org/10.3324/haematol.2013.087742

Linezolid induces ring sideroblasts

Christophe Willekens, Florent Dumezy, Thomas Boyer, Aline Renneville, Julien Rossignol, Céline Berthon, Angélique Cotteau-Leroy, Lotfi Mehiaoui, Bruno Quesnel, Claude Preudhomme

https://doi.org/10.3324/haematol.2013.092395

Use of prothrombin complex concentrates for urgent reversal of dabigatran in the Emergency Department

Manuel Quintana Díaz, Alberto M. Borobia, Ma Angelica Rivera Núñez, Ana Maria Martínez Virto, Sara Fabra, Marcelino Sánchez Casado, Jose A. García-Erce, C. Meyer Samama

https://doi.org/10.3324/haematol.2013.092767