March, 2012
No. 97 (3)

Editorials

Articles

Oxygen tension plays a critical role in the hematopoietic microenvironment in vitro

Duohui Jing, Manja Wobus, David M. Poitz, Martin Bornhäuser, Gerhard Ehninger, Rainer Ordemann

https://doi.org/10.3324/haematol.2011.050815

Epigenetic inactivation of TWIST2 in acute lymphoblastic leukemia modulates proliferation, cell survival and chemosensitivity

Shabnam H. Thathia, Stuart Ferguson, Hannah E. Gautrey, Sanne D. van Otterdijk, Michela Hili, Vikki Rand, Anthony V. Moorman, Stefan Meyer, Robert Brown, Gordon Strathdee

https://doi.org/10.3324/haematol.2011.049593

Functional analysis of the NUP98-CCDC28A fusion protein

Arnaud Petit, Christine Ragu, Gwendoline Soler, Chris Ottolenghi, Caroline Schluth, Isabelle Radford-Weiss, Sylvie Schneider-Maunoury, Isabelle Callebaut, Nicole Dastugue, Harry A. Drabkin, Olivier A. Bernard, Serge Romana, Virginie Penard-Lacronique

https://doi.org/10.3324/haematol.2011.047969

Acquired mutations in ASXL1 in acute myeloid leukemia: prevalence and prognostic value

Marta Pratcorona, Saman Abbas, Mathijs A. Sanders, Jasper E. Koenders, François G. Kavelaars, Claudia A.J. Erpelinck-Verschueren, Annelieke Zeilemakers, Bob Löwenberg, Peter J.M. Valk

https://doi.org/10.3324/haematol.2011.051532

A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy

Michael Lübbert, Björn H. Rüter, Rainer Claus, Claudia Schmoor, Mathias Schmid, Ulrich Germing, Andrea Kuendgen, Volker Rethwisch, Arnold Ganser, Uwe Platzbecker, Oliver Galm, Wolfram Brugger, Gerhard Heil, Björn Hackanson, Barbara Deschler, Konstanze Döhner, Anne Hagemeijer, Pierre W. Wijermans, Hartmut Döhner

https://doi.org/10.3324/haematol.2011.048231

Low platelet counts after induction therapy for childhood acute lymphoblastic leukemia are strongly associated with poor early response to treatment as measured by minimal residual disease and are prognostic for treatment outcome

Lutz Zeidler, Martin Zimmermann, Anja Möricke, Barbara Meissner, Dorothee Bartels, Christoph Tschan, André Schrauder, Gunnar Cario, Lilia Goudeva, Sarah Jäger, Richard Ratei, Wolf-Dieter Ludwig, Andrea Teigler-Schlegel, Julia Skokowa, Rolf Koehler, Claus R. Bartram, Hansjörg Riehm, Martin Schrappe, Karl Welte, Martin Stanulla

https://doi.org/10.3324/haematol.2011.045229

NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL

Ilaria Del Giudice, Davide Rossi, Sabina Chiaretti, Marilisa Marinelli, Simona Tavolaro, Sara Gabrielli, Luca Laurenti, Roberto Marasca, Silvia Rasi, Marco Fangazio, Anna Guarini, Gianluca Gaidano, Robin Foà

https://doi.org/10.3324/haematol.2011.060129

Cyclophosphamide, thalidomide, and dexamethasone as induction therapy for newly diagnosed multiple myeloma patients destined for autologous stem-cell transplantation: MRC Myeloma IX randomized trial results

Gareth J. Morgan, Faith E. Davies, Walter M. Gregory, Sue E. Bell, Alexander J. Szubert, Nuria Navarro Coy, Gordon Cook, Sylvia Feyler, Peter R.E. Johnson, Claudius Rudin, Mark T. Drayson, Roger G. Owen, Fiona M. Ross, Nigel H. Russell, Graham H. Jackson, J. Anthony Child

https://doi.org/10.3324/haematol.2011.043372

Overlap subtype of chronic graft-versus-host disease is associated with an adverse prognosis, functional impairment, and inferior patient-reported outcomes: a Chronic Graft-versus-Host Disease Consortium study

Joseph Pidala, Georgia Vogelsang, Paul Martin, Xiaoyu Chai, Barry Storer, Steven Pavletic, Daniel J. Weisdorf, Madan Jagasia, Corey Cutler, Jeanne Palmer, David Jacobsohn, Sally Arai, Stephanie J. Lee

https://doi.org/10.3324/haematol.2011.055186

Universal antifungal therapy is not needed in persistent febrile neutropenia: a tailored diagnostic and therapeutic approach

Manuela Aguilar-Guisado, Almudena Martín-Peña, Ildefonso Espigado, Maite Ruiz Pérez de Pipaon, José Falantes, Fátima de la Cruz, José M. Cisneros

https://doi.org/10.3324/haematol.2011.049999

Letters to the Editor

Iron deficiency does not compromise the diagnosis of high HbA2 β thalassemia trait

Cristina Passarello, Antonino Giambona, Monica Cannata, Margherita Vinciguerra, Disma Renda, Aurelio Maggio

https://doi.org/10.3324/haematol.2011.052357

Online Only Articles

Hematology News

Original Articles and Brief Reports

Thrombolytic therapy is effective in paroxysmal nocturnal hemoglobinuria: a series of nine patients and a review of the literature

David J. Araten, Rosario Notaro, Howard T Thaler, Nancy Kernan, Farid Boulad, Hugo Castro-Malaspina, Trudy Small, Andromachi Scaradavou, Heather Magnan, Susan Prockop, Sara Chaffee, Jason Gonsky, Raymond Thertulien, Roberto Tarquini, Lucio Luzzatto

https://doi.org/10.3324/haematol.2011.049767

Telomere length is associated with disease severity and declines with age in dyskeratosis congenita

Blanche P. Alter, Philip S. Rosenberg, Neelam Giri, Gabriela M. Baerlocher, Peter M. Lansdorp, Sharon A. Savage

https://doi.org/10.3324/haematol.2011.055269

A risk of essential thrombocythemia in carriers of constitutional CHEK2 gene mutations

Hanna Janiszewska, Aneta Bąk, Maria Pilarska, Marta Heise, Anna Junkiert-Czarnecka, Małgorzata Kuliszkiewicz-Janus, Małgorzata Całbecka, Bożena JaŸwiec, Dariusz Wołowiec, Kazimierz Kuliczkowski, Olga Haus

https://doi.org/10.3324/haematol.2011.049494

Plasma thymus and activation-regulated chemokine as an early response marker in classical Hodgkin’s lymphoma

Wouter J. Plattel, Anke van den Berg, Lydia Visser, Anne-Marijn van der Graaf, Jan Pruim, Hans Vos, Bouke Hepkema, Arjan Diepstra, Gustaaf W. van Imhoff

https://doi.org/10.3324/haematol.2011.053199

Salvage treatment with lenalidomide and dexamethasone in relapsed/refractory mantle cell lymphoma: clinical results and effects on microenvironment and neo-angiogenic biomarkers

Francesco Zaja, Stefano De Luca, Umberto Vitolo, Lorella Orsucci, Alessandro Levis, Flavia Salvi, Chiara Rusconi, Erika Ravelli, Alessandra Tucci, Chiara Bottelli, Monica Balzarotti, Ercole Brusamolino, Maurizio Bonfichi, Stefano A. Pileri, Elena Sabattini, Stefano Volpetti, Chiara Monagheddu, Angelo Vacca, Roberto Ria, Renato Fanin

https://doi.org/10.3324/haematol.2011.051813

Flavopiridol treatment of patients aged 70 or older with refractory or relapsed chronic lymphocytic leukemia is a feasible and active therapeutic approach

Deborah M. Stephens, Amy S. Ruppert, Kristie Blum, Jeffrey Jones, Joseph M. Flynn, Amy J. Johnson, Jia Ji, Mitch A. Phelps, Michael R. Grever, John C. Byrd

https://doi.org/10.3324/haematol.2011.047324