Vol. 96 No. 4 (2011): April, 2011

Novel observations in hereditary hemochromatosis: potential implications for clinical strategies (1226 Online Views)

Dorine W. Swinkels, Robert E. Fleming

https://doi.org/10.3324/haematol.2011.042036

The rationale for using hydroxycarbamide in the treatment of sickle cell disease (1212 Online Views)

David C. Rees

https://doi.org/10.3324/haematol.2011.041988

Acute myeloid leukemia with monosomal karyotype at the far end of the unfavorable prognostic spectrum (1238 Online Views)

Dimitri A. Breems, Bob Löwenberg

https://doi.org/10.3324/haematol.2011.043208

Therapy-related acute promyelocytic leukemia (534 Online Views)

Farhad Ravandi

https://doi.org/10.3324/haematol.2011.041970

Mediastinal gray zone lymphoma (1184 Online Views)

Leticia Quintanilla-Martinez, Falko Fend

https://doi.org/10.3324/haematol.2011.043026

The Ph-positive and Ph-negative myeloproliferative neoplasms: some topical pre-clinical and clinical issues (1753 Online Views)

Richard A. Van Etten, Steffen Koschmieder, Francois Delhommeau, Danilo Perrotti, Tessa Holyoake, Animesh Pardanani, Ruben Mesa, Tony Green, Amr R. Ibrahim, Tariq Mughal, Robert Peter Gale, John Goldman

https://doi.org/10.3324/haematol.2010.035675

A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis (1104 Online Views)

Domenico Girelli, Paola Trombini, Fabiana Busti, Natascia Campostrini, Marco Sandri, Sara Pelucchi, Mark Westerman, Tomas Ganz, Elizabeta Nemeth, Alberto Piperno, Clara Camaschella

https://doi.org/10.3324/haematol.2010.033449

Iron overload in HFE C282Y heterozygotes at first genetic testing: a strategy for identifying rare HFE variants (3428 Online Views)

Patricia Aguilar-Martinez, Bernard Grandchamp, Séverine Cunat, Estelle Cadet, François Blanc, Marlène Nourrit, Kaiss Lassoued, Jean-François Schved, Jacques Rochette

https://doi.org/10.3324/haematol.2010.029751

Cardiac iron and cardiac disease in males and females with transfusion-dependent thalassemia major: a T2* magnetic resonance imaging study (1311 Online Views)

Maria Marsella, Caterina Borgna-Pignatti, Antonella Meloni, Valeria Caldarelli, Maria Chiara Dell’Amico, Anna Spasiano, Lorella Pitrolo, Eliana Cracolici, Gianluca Valeri, Vincenzo Positano, Massimo Lombardi, Alessia Pepe

https://doi.org/10.3324/haematol.2010.025510

A phase 1 dose-escalation study: safety, tolerability, and pharmacokinetics of FBS0701, a novel oral iron chelator for the treatment of transfusional iron overload (941 Online Views)

Hugh Young Rienhoff, Vip Viprakasit, Lay Tay, Paul Harmatz, Elliott Vichinsky, Deborah Chirnomas, Janet L. Kwiatkowski, Amy Tapper, William Kramer, John B. Porter, Ellis J. Neufeld

https://doi.org/10.3324/haematol.2010.034405

Participation of Mac-1, LFA-1 and VLA-4 integrins in the in vitro adhesion of sickle cell disease neutrophils to endothelial layers, and reversal of adhesion by simvastatin (667 Online Views)

Andreia A. Canalli, Renata F. Proença, Carla F. Franco-Penteado, Fabiola Traina, Tatiana M. Sakamoto, Sara T. O. Saad, Nicola Conran, Fernando F. Costa

https://doi.org/10.3324/haematol.2010.032912

Differential modulation of adhesion molecule expression by hydroxycarbamide in human endothelial cells from the micro- and macrocirculation: potential implications in sickle cell disease vasoocclusive events (1661 Online Views)

Sandrine Laurance, Pauline Lansiaux, François-Xavier Pellay, Michelle Hauchecorne, Arndt Benecke, Jacques Elion, Claudine Lapoumeroulie

https://doi.org/10.3324/haematol.2010.026740

Establishment of a xenograft model of human myelodysplastic syndromes (1051 Online Views)

Yukari Muguruma, Hiromichi Matsushita, Takashi Yahata, Shizu Yumino, Yumiko Tanaka, Hayato Miyachi, Yoshiaki Ogawa, Hiroshi Kawada, Mamoru Ito, Kiyoshi Ando

https://doi.org/10.3324/haematol.2010.027557

Philadelphia-positive acute lymphoblastic leukemia patients already harbor BCR-ABL kinase domain mutations at low levels at the time of diagnosis (1417 Online Views)

Simona Soverini, Antonella Vitale, Angela Poerio, Alessandra Gnani, Sabrina Colarossi, Ilaria Iacobucci, Giuseppe Cimino, Loredana Elia, Annalisa Lonetti, Marco Vignetti, Stefania Paolini, Giovanna Meloni, Valeria di Maio, Cristina Papayannidis, Marilina Amabile, Anna Guarini, Michele Baccarani, Giovanni Martinelli, Robin Foà

https://doi.org/10.3324/haematol.2010.034173

Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin’s lymphoma and primary mediastinal large B-cell lymphoma (1597 Online Views)

Franziska C. Eberle, Jaime Rodriguez-Canales, Lai Wei, Jeffrey C. Hanson, J. Keith Killian, Hong-Wei Sun, Lisa G. Adams, Stephen M. Hewitt, Wyndham H. Wilson, Stefania Pittaluga, Paul S. Meltzer, Louis M. Staudt, Michael R. Emmert-Buck, Elaine S. Jaffe

https://doi.org/10.3324/haematol.2010.033167

Subcutaneous injections of low-dose veltuzumab (humanized anti-CD20 antibody) are safe and active in patients with indolent non-Hodgkin’s lymphoma (1086 Online Views)

George O. Negrea, Rebecca Elstrom, Steven L. Allen, Kanti R. Rai, Rashid M. Abbasi, Charles M. Farber, Nick Teoh, Heather Horne, William A. Wegener, David M. Goldenberg

https://doi.org/10.3324/haematol.2010.037390

A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines (2849 Online Views)

Jérôme Moreaux, Bernard Klein, Régis Bataille, Géraldine Descamps, Sophie Maïga, Dirk Hose, Hartmut Goldschmidt, Anna Jauch, Thierry Rème, Michel Jourdan, Martine Amiot, Catherine Pellat-Deceunynck

https://doi.org/10.3324/haematol.2010.033456

Vitamin K1 supplementation to improve the stability of anticoagulation therapy with vitamin K antagonists: a dose-finding study (1318 Online Views)

Edward P.A. Gebuis, Frits R. Rosendaal, Erik van Meegen, Felix J.M. van der Meer

https://doi.org/10.3324/haematol.2010.035162

Cytokine signature profiles in acquired aplastic anemia and myelodysplastic syndromes (1962 Online Views)

Xingmin Feng, Phillip Scheinberg, Colin O. Wu, Leigh Samsel, Olga Nunez, Courtney Prince, Rebecca D. Ganetzky, J. Philip McCoy, Jaroslaw P. Maciejewski, Neal S. Young

https://doi.org/10.3324/haematol.2010.030536

Deep sequencing reveals double mutations in cis of MPL exon 10 in myeloproliferative neoplasms (1108 Online Views)

Daniela Pietra, Angela Brisci, Elisa Rumi, Sabrina Boggi, Chiara Elena, Alessandro Pietrelli, Roberta Bordoni, Maurizio Ferrari, Francesco Passamonti, Gianluca De Bellis, Laura Cremonesi, Mario Cazzola

https://doi.org/10.3324/haematol.2010.034793

Presenting features and treatment outcome of acute promyelocytic leukemia arising after multiple sclerosis (600 Online Views)

Emanuele Ammatuna, Pau Montesinos, Syed Khizer Hasan, Safaa M. Ramadan, Jordi Esteve, Maximillian Hubmann, Maria Pagoni, David Grimwade, Miguel Angel Sanz, Francesco Lo-Coco

https://doi.org/10.3324/haematol.2010.036657

White blood cell count at diagnosis and immunoglobulin variable region gene mutations are independent predictors of treatment-free survival in young patients with stage A chronic lymphocytic leukemia (1131 Online Views)

Ilaria Del Giudice, Francesca Romana Mauro, Maria Stefania De Propris, Simona Santangelo, Marilisa Marinelli, Nadia Peragine, Valeria Di Maio, Mauro Nanni, Rita Barzotti, Francesca Mancini, Daniele Armiento, Francesca Paoloni, Anna Guarini, Robin Foà

https://doi.org/10.3324/haematol.2010.028779

Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy (2069 Online Views)

Benoist Pruvot, Arnaud Jacquel, Nathalie Droin, Patrick Auberger, Didier Bouscary, Jérome Tamburini, Marc Muller, Michaela Fontenay, Johanna Chluba, Eric Solary

https://doi.org/10.3324/haematol.2010.031401

The CEBPA gene is down-regulated in acute promyelocytic leukemia and its upstream promoter, but not the core promoter, is highly methylated (1605 Online Views)

Bárbara Amélia Santana-Lemos, Ana Paula Alencar de Lima Lange, Mariana Tereza de Lira Benício, Thiago Donizete da Silva José, Antônio Roberto Lucena-Araújo, Alexandre Krause, Carolina Hassibe Thomé, Eduardo Magalhães Rego

https://doi.org/10.3324/haematol.2010.028365