CO49 | Combined nf1/suz12 haploinsufficiency drives aberrant activation of the RAS signaling cascade in immature hoxa-positive T-ALL (100 Online Views)

V. Bardelli¹, L. Pagliaro², V. Pierini³, S. Arniani¹, F. Servoli¹, M. Lucarelli¹, S. Sica⁴, M. Cerrano⁵, F. Giglio⁶, M. Delia⁷, B. Cambo’⁸, M. Annunziata⁹, S. Trappolini¹⁰, F. Forghieri¹¹, M. Lunghi¹², P. Zappasodi¹³, M. Piccini¹⁴, C. Matteucci¹, A. Tafuri¹⁵, P. Grammatico¹⁶, Mp. Martelli¹, C. Mecucci¹, G. Roti², R. La Starza¹ | ¹Hematology and Bone Marrow Transplantation Unit, Department of Medicine and Surgery, University of Perugia; {2}Department of Medicine and Surgery, University of Parma, Parma, Italy; Hematology and BMT Unit, Azienda Ospedaliero Universitaria di Parma, Parma, Italy, Translational Hematology and Chemogenomics, University of Parma; {3}Laboratory of Molecular Medicine and Cytogenetics. Hematology Unit, CREO, Azienda Ospedaliera di Perugia; {4}Dipartimento di Scienze di Laboratorio ed Ematologiche-Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore; {5}Department of Molecular Biotechnology and Health Sciences, Division of Hematology, University of Turin; {6}Hematology and Bone Marrow Transplantation Unit, IRCCS Ospedale San Raffaele; {7}Hematology and Stem Cell Transplantation Unit, AOUC Policlinico of Bari; {8}Hematology and BMT Unit, Azienda Ospedaliero-Universitaria di Parma; {9}Hematology Unit, Hospital 'Antonio Cardarelli'; {10}Hematology Clinic, Azienda Ospedaliero Universitaria delle Marche; {11}Section of Hematology, Department of Oncology and Hematology. Azienda Ospedaliero-Universitaria di Modena; {12}University of Piemonte Orientale; {13}Division of Hematology, Foundation, IRCCS Policlinico San Matteo, Pavia; {14}SOD Hematology, University of Florence, AOU Careggi; {15}Hematology, Department of Biotecnologie Cellulari ed Ematologia, Sapienza, University of Rome; {16}Division of Medical Genetics, Department of Experimental Medicine, San Camillo-Forlanini Hospital, Sapienza University

CO54 | Biallelic loss of RB1 and LPAR6 at 13q14 drives key cell cycle abnormalities in T-cell acute lymphoblastic leukemia (119 Online Views)

F. Servoli¹, M. Giaimo², V. Pierini³, V. Bardelli¹, S. Arniani¹, M. Lucarelli¹, C. Matteucci¹, B. Crescenzi³, S. Romoli³, L. Pagliaro², R. Zamponi², A. Fiou⁴, M. Vecchi⁵, F. Landuzzi⁴, F. Forghieri⁶, A. Curti⁷, B. Cambò², C. Pasciolla⁸, F. Lessi⁹, F. Lussana¹⁰, A. Cavalli^4|11|12, G. Roti², M.P. Martelli¹, R. La Starza¹ | ¹Hematology and Bone Marrow Transplantation Unit, Department of Medicine and Surgery, University of Perugia; ²Department of Medicine and Surgery, University of Parma; Hematology and BMT Unit, Azienda Ospedaliero Universitaria di Parma; Translational Hematology and Chemogenomics ^THEC, University of Parma; ³Laboratory of Molecular Medicine and Cytogenetics. Hematology Unit, CREO, Azienda Ospedaliera di Perugia; ⁴Center for Clinical and Computational Genomics, Computational and Chemical Biology, Fondazione Istituto Italiano di Tecnologia ^IIT; ⁵Center for Clinical and Computational Genomics, Non-coding RNAs and RNA-based therapeutics, Fondazione Istituto Italiano di Tecnologia ^IIT; ⁶Section of Hematology, Department of Oncology and Hematology. Azienda Ospedaliero-Universitaria di Modena; ⁷IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”; ⁸Hematology Unit, IRCCS Istituto Tumori "Giovanni Paolo II"; ⁹Department of Medicine, Hematology and Clinical Immunology Unit, University of Padova; ¹⁰Department of Oncology and Hematology, University of Milan and Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII; ¹¹Center for Human Technologies, Computational and Chemical Biology, Fondazione Istituto Italiano di Tecnologia ^IIT; ¹²Centre Européen de Calcul Atomique et Moléculaire ^CECAM, Ecole Polytechnique Fédérale de Lausanne

Clonal megakaryocyte dysplasia with normal blood values: a covert, thrombosis-prone, early myeloproliferative neoplasm (780 Online Views)

Giovanni Barosi, Vittorio Rosti, Rita Campanelli, Margherita Massa, Carlotta Abbà, Adriana Carolei, Paolo Catarsi, Alessandro Inzoli, Lorena Pergola, Tiziano Barbui, Caterina Tatarelli, Maria Chiara Finazzi, Annalisa Condorelli, Silvia Salmoiraghi, Alessandro Rambaldi, Andrea Gianatti, Valerio De Stefano, Anna Gallì, Martina Gandossini, Michela Bardelli, Robert Peter Gale, Luca Malcovati

Ex vivo drug response profiling guides therapy in a case of high-risk acute undifferentiated leukemia with PICALM::MLLT10 (3001 Online Views)

Elena Mastrodicasa, Luca Pagliaro, Valentina Pierini, Valentina Bardelli, Mariateresa Giaimo, Raffaella Zamponi, Anna Montanaro, Katia Tragni, Roberta Arcaleni, Maria Speranza Massei, Ilaria Capolsini, Katia Perruccio, Elena Varotto, Barbara Buldini, Andrea Gherli, Silvia Romoli, Caterina Matteucci, Maria Crocioni, Francesco Arcioni, Grazia Gurdo, Carla Cerri, Maurizio Caniglia, Giovanni Roti, Roberta La Starza