CO54 | Biallelic loss of RB1 and LPAR6 at 13q14 drives key cell cycle abnormalities in T-cell acute lymphoblastic leukemia (119 Online Views)

F. Servoli¹, M. Giaimo², V. Pierini³, V. Bardelli¹, S. Arniani¹, M. Lucarelli¹, C. Matteucci¹, B. Crescenzi³, S. Romoli³, L. Pagliaro², R. Zamponi², A. Fiou⁴, M. Vecchi⁵, F. Landuzzi⁴, F. Forghieri⁶, A. Curti⁷, B. Cambò², C. Pasciolla⁸, F. Lessi⁹, F. Lussana¹⁰, A. Cavalli^4|11|12, G. Roti², M.P. Martelli¹, R. La Starza¹ | ¹Hematology and Bone Marrow Transplantation Unit, Department of Medicine and Surgery, University of Perugia; ²Department of Medicine and Surgery, University of Parma; Hematology and BMT Unit, Azienda Ospedaliero Universitaria di Parma; Translational Hematology and Chemogenomics ^THEC, University of Parma; ³Laboratory of Molecular Medicine and Cytogenetics. Hematology Unit, CREO, Azienda Ospedaliera di Perugia; ⁴Center for Clinical and Computational Genomics, Computational and Chemical Biology, Fondazione Istituto Italiano di Tecnologia ^IIT; ⁵Center for Clinical and Computational Genomics, Non-coding RNAs and RNA-based therapeutics, Fondazione Istituto Italiano di Tecnologia ^IIT; ⁶Section of Hematology, Department of Oncology and Hematology. Azienda Ospedaliero-Universitaria di Modena; ⁷IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”; ⁸Hematology Unit, IRCCS Istituto Tumori "Giovanni Paolo II"; ⁹Department of Medicine, Hematology and Clinical Immunology Unit, University of Padova; ¹⁰Department of Oncology and Hematology, University of Milan and Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII; ¹¹Center for Human Technologies, Computational and Chemical Biology, Fondazione Istituto Italiano di Tecnologia ^IIT; ¹²Centre Européen de Calcul Atomique et Moléculaire ^CECAM, Ecole Polytechnique Fédérale de Lausanne