November, 2017
No. 102 (11)

Editorials

Articles

Red Cell Biology & its Disorders

Clinical risks and healthcare utilization of hematopoietic cell transplantation for sickle cell disease in the USA using merged databases (487 Online Views)

Staci D. Arnold, Ruta Brazauskas, Naya He, Yimei Li, Richard Aplenc, Zhezhen Jin, Matt Hall, Yoshiko Atsuta, Jignesh Dalal, Theresa Hahn, Nandita Khera, Carmem Bonfim, Navneet S. Majhail, Miguel Angel Diaz, Cesar O. Freytes, William A. Wood, Bipin N. Savani, Rammurti T. Kamble, Susan Parsons, Ibrahim Ahmed, Keith Sullivan, Sara Beattie, Christopher Dandoy, Reinhold Munker, Susana Marino, Menachem Bitan, Hisham Abdel-Azim, Mahmoud Aljurf, Richard F. Olsson, Sarita Joshi, Dave Buchbinder, Michael J. Eckrich, Shahrukh Hashmi, Hillard Lazarus, David I. Marks, Amir Steinberg, Ayman Saad, Usama Gergis, Lakshmanan Krishnamurti, Allistair Abraham, Hemalatha G. Rangarajan, Mark Walters, Joseph Lipscomb, Wael Saber, Prakash Satwani

https://doi.org/10.3324/haematol.2017.169581

Coagulation & its Disorders

The ADAMTS131239–1253 peptide is a dominant HLA-DR1-restricted CD4+ T-cell epitope (235 Online Views)

Laurent Gilardin, Sandrine Delignat, Ivan Peyron, Mathieu Ing, Yu-Chun Lone, Bagirath Gangadharan, Baptiste Michard, Yousra Kherabi, Meenu Sharma, Anastas Pashov, Jean-Baptiste Latouche, Mohamad Hamieh, Olivier Toutirais, Pascale Loiseau, Lionel Galicier, Agnès Veyradier, Srini Kaveri, Bernard Maillère, Paul Coppo, Sébastien Lacroix-Desmazes

https://doi.org/10.3324/haematol.2015.136671

Chronic Myeloid Leukemia

Treatment outcome in a population-based, ‘real-world’ cohort of patients with chronic myeloid leukemia (291 Online Views)

Inge G.P. Geelen, Noortje Thielen, Jeroen J.W.M. Janssen, Mels Hoogendoorn, Tanja J.A. Roosma, Sten P. Willemsen, Otto Visser, Jan J. Cornelissen, Peter E. Westerweel

https://doi.org/10.3324/haematol.2017.174953

Acute Myeloid Leukemia

Senescence is a Spi1-induced anti-proliferative mechanism in primary hematopoietic cells (461 Online Views)

Laure Delestré, Hengxiang Cui, Michela Esposito, Cyril Quiveron, Elena Mylonas, Virginie Penard-Lacronique, Oliver Bischof, Christel Guillouf

https://doi.org/10.3324/haematol.2016.157636

Bortezomib as a new therapeutic approach for blastic plasmacytoid dendritic cell neoplasm (346 Online Views)

Laure Philippe, Adam Ceroi, Elodie Bôle-Richard, Alizée Jenvrin, Sabeha Biichle, Sophie Perrin, Samuel Limat, Francis Bonnefoy, Eric Deconinck, Philippe Saas, Francine Garnache-Ottou, Fanny Angelot-Delettre

https://doi.org/10.3324/haematol.2017.169326

Acute Lymphoblastic Leukemia

Antigen receptor sequencing of paired bone marrow samples shows homogeneous distribution of acute lymphoblastic leukemia subclones (170 Online Views)

Prisca M.J. Theunissen, David van Zessen, Andrew P. Stubbs, Malek Faham, Christian M. Zwaan, Jacques J.M. van Dongen, Vincent H.J. Van Der Velden

https://doi.org/10.3324/haematol.2017.171454

Chronic Lymphocytic Leukemia

Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cells by a novel NF-κB inhibitor (369 Online Views)

Tiziana Vaisitti, Federica Gaudino, Samedy Ouk, Maria Moscvin, Nicoletta Vitale, Sara Serra, Francesca Arruga, Johannes L. Zakrzewski, Hsiou-Chi Liou, John N. Allan, Richard R. Furman, Silvia Deaglio

https://doi.org/10.3324/haematol.2017.173419

SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia (342 Online Views)

Cody Paiva, Taylor A. Rowland, Bhargava Sreekantham, Claire Godbersen, Scott R. Best, Prabhjot Kaur, Marc M. Loriaux, Stephen E.F. Spurgeon, Olga V. Danilova, Alexey V. Danilov

https://doi.org/10.3324/haematol.2017.170571

Chronic Lymphoblastic Leukemia

Toll-like receptor 9 stimulation can induce IκBζ expression and IgM secretion in chronic lymphocytic leukemia cells (225 Online Views)

Eleonora Fonte, Maria Giovanna Vilia, Daniele Reverberi, Ilenia Sana, Lydia Scarfò, Pamela Ranghetti, Ugo Orfanelli, Simone Cenci, Giovanna Cutrona, Paolo Ghia, Marta Muzio

https://doi.org/10.3324/haematol.2017.165878

Non-Hodgkin Lymphoma

Efficacy and safety of subcutaneous and intravenous rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in first-line diffuse large B-cell lymphoma: the randomized MabEase study (542 Online Views)

Pieternella Lugtenburg, Irit Avivi, Henriette Berenschot, Osman Ilhan, Jean Pierre Marolleau, Arnon Nagler, Antonio Rueda, Monica Tani, Mehmet Turgut, Stuart Osborne, Rodney Smith, Michael Pfreundschuh

https://doi.org/10.3324/haematol.2017.173583

Italian real-life experience with brentuximab vedotin: results of a large observational study of 40 cases of relapsed/refractory systemic anaplastic large cell lymphoma (244 Online Views)

Alessandro Broccoli, Cinzia Pellegrini, Alice Di Rocco, Benedetta Puccini, Caterina Patti, Guido Gini, Donato Mannina, Monica Tani, Chiara Rusconi, Alessandra Romano, Anna Vanazzi, Barbara Botto, Carmelo Carlo-Stella, Stefan Hohaus, Pellegrino Musto, Patrizio Mazza, Stefano Molica, Paolo Corradini, Angelo Fama, Francesco Gaudio, Michele Merli, Angela Gravetti, Giuseppe Gritti, Annalisa Arcari, Patrizia Tosi, Anna Marina Liberati, Antonello Pinto, Vincenzo Pavone, Filippo Gherlinzoni, Virginia Naso, Stefano Volpetti, Livio Trentin, Maria Cecilia Goldaniga, Maurizio Bonfichi, Amalia De Renzo, Corrado Schiavotto, Michele Spina, Sergio Storti, Angelo Michele Carella, Vittorio Stefoni, Lisa Argnani, Pier Luigi Zinzani

https://doi.org/10.3324/haematol.2017.171355

Cell Therapy & Immunotherapy

CD56bright natural killer regulatory cells in filgrastim primed donor blood or marrow products regulate chronic graft-versus-host disease: the Canadian Blood and Marrow Transplant Group randomized 0601 study results (154 Online Views)

Amina Kariminia, Sabine Ivison, Bernard Ng, Jacob Rozmus, Susanna Sung, Avani Varshney, Mahmoud Aljurf, Sylvie Lachance, Irwin Walker, Cindy Toze, Jeff Lipton, Stephanie J. Lee, Jeff Szer, Richard Doocey, Ian Lewis, Clayton Smith, Naeem Chaudhri, Megan K. Levings, Raewyn Broady, Gerald Devins, David Szwajcer, Ronan Foley, Sara Mostafavi, Steven Pavletic, Donna A. Wall, Stephan Couban, Tony Panzarella, Kirk R. Schultz

https://doi.org/10.3324/haematol.2017.170928

Human leukocyte antigen-E mismatch is associated with better hematopoietic stem cell transplantation outcome in acute leukemia patients (200 Online Views)

Chrysanthi Tsamadou, Daniel Fürst, Vladan Vucinic, Donald Bunjes, Christine Neuchel, Daphne Mytilineos, Martin Gramatzki, Renate Arnold, Eva Maria Wagner, Hermann Einsele, Carlheinz Müller, Hubert Schrezenmeier, Joannis Mytilineos

https://doi.org/10.3324/haematol.2017.169805

Complications in Hematology

HIF1A is a critical downstream mediator for hemophagocytic lymphohistiocytosis (597 Online Views)

Rui Huang, Yoshihiro Hayashi, Xiaomei Yan, Jiachen Bu, Jieyu Wang, Yue Zhang, Yile Zhou, Yuting Tang, Lingyun Wu, Zefeng Xu, Xin Liu, Qianfei Wang, Jianfeng Zhou, Zhijian Xiao, James P. Bridges, Rebecca A. Marsh, Kejian Zhang, Michael B. Jordan, Yuhua Li, Gang Huang

https://doi.org/10.3324/haematol.2017.174979

Guidelines

Haploidentical hematopoietic cell transplantation for adult acute myeloid leukemia: a position statement from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (1359 Online Views)

Catherine J Lee, Bipin N Savani, Mohamad Mohty, Myriam Labopin, Annalisa Ruggeri, Christoph Schmid, Frédéric Baron, Jordi Esteve, Norbert C Gorin, Sebastian Giebel, Fabio Ciceri, Arnon Nagler

https://doi.org/10.3324/haematol.2017.176107

Online Only Articles

Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow (262 Online Views)

Erica L. Clinkenbeard, Mark R. Hanudel, Keith R. Stayrook, Hitesh Nidumanda Appaiah, Emily G. Farrow, Taryn A. Cass, Lelia J. Summers, Colin S. Ip, Julia M. Hum, Joseph C. Thomas, Mircea Ivan, Briana M. Richine, Rebecca J. Chan, Thomas L. Clemens, Ernestina Schipani, Yves Sabbagh, Linlin Xu, Edward F. Srour, Marta B. Alvarez, Melissa A. Kacena, Isidro B. Salusky, Tomas Ganz, Elizabeta Nemeth, Kenneth E. White

https://doi.org/10.3324/haematol.2017.167882

Increase of von Willebrand factor with aging in type 1 von Willebrand disease: fact or fiction? (122 Online Views)

Mariachiara Borghi, Giuseppe Guglielmini, Anna Maria Mezzasoma, Emanuela Falcinelli, Loredana Bury, Marco Malvestiti, Paolo Gresele

https://doi.org/10.3324/haematol.2017.168013

MLL-TET1 fusion protein promotes immortalization of myeloid progenitor cells and leukemia development (194 Online Views)

Hyeng-Soo Kim, Seung Hwan Oh, Ju-Heon Kim, Jae-Young Kim, Do-Hyung Kim, Soo-Jin Lee, Sang-Un Choi, Kwon Moo Park, Zae Young Ryoo, Tae Sung Park, Sanggyu Lee

https://doi.org/10.3324/haematol.2017.169789

The role of constitutive activation of FMS-related tyrosine kinase-3 and NRas/KRas mutational status in infants with KMT2A-rearranged acute lymphoblastic leukemia (211 Online Views)

Henning Fedders, Ameera Alsadeq, Juliane Schmäh, Fotini Vogiatzi, Martin Zimmermann, Anja Möricke, Lennart Lenk, Udo zur Stadt, Martin A. Horstmann, Rob Pieters, Martin Schrappe, Martin Stanulla, Gunnar Cario, Denis M. Schewe

https://doi.org/10.3324/haematol.2017.169870

Mutational status of IGHV is the most reliable prognostic marker in trisomy 12 chronic lymphocytic leukemia (232 Online Views)

Pietro Bulian, Riccardo Bomben, Michele Dal Bo, Antonella Zucchetto, Francesca Maria Rossi, Massimo Degan, Federico Pozzo, Tamara Bittolo, Vanessa Bravin, Tiziana D’Agaro, Michaela Cerri, Annalisa Chiarenza, Kari G. Chaffee, Adalgisa Condoluci, Giovanni D’Arena, Michele Spina, Francesco Zaja, Gabriele Pozzato, Francesco Di Raimondo, Davide Rossi, Giovanni Del Poeta, Gianluca Gaidano, Tait D. Shanafelt, Valter Gattei

https://doi.org/10.3324/haematol.2017.170340

The Bruton tyrosine kinase inhibitor CC-292 shows activity in mantle cell lymphoma and synergizes with lenalidomide and NIK inhibitors depending on nuclear factor-κB mutational status (284 Online Views)

Anna Vidal-Crespo, Vanina Rodriguez, Alba Matas-Cespedes, Eriong Lee, Alfredo Rivas-Delgado, Eva Giné, Alba Navarro, Sílvia Beà, Elias Campo, Armando López-Guillermo, Monica Lopez-Guerra, Gaël Roué, Dolors Colomer, Patricia Pérez-Galán

https://doi.org/10.3324/haematol.2017.168930

CXCL13 levels are elevated in patients with Waldenström macroglobulinemia, and are predictive of major response to ibrutinib (120 Online Views)

Josephine M. Vos, Nickolas Tsakmaklis, Christopher J. Patterson, Kirsten Meid, Jorge J. Castillo, Philip Brodsky, Tomas Ganz, Steven T. Pals, Marie José Kersten, Lian Xu, Guang Yang, Steven P. Treon, Zachary R. Hunter

https://doi.org/10.3324/haematol.2017.172627

Mass spectrometry-based identification of a naturally presented receptor tyrosine kinase-like orphan receptor 1-derived epitope recognized by CD8+ cytotoxic T cells (255 Online Views)

Falk Heidenreich, Elke Rücker-Braun, Juliane S. Walz, Anne Eugster, Denise Kühn, Sevina Dietz, Annika Nelde, Antje Tunger, Rebekka Wehner, Cornelia S. Link, Jan M. Middeke, Friedrich Stölzel, Torsten Tonn, Stefan Stevanovic, Hans-Georg Rammensee, Ezio Bonifacio, Michael Bachmann, Matthias Zeis, Gerhard Ehninger, Martin Bornhäuser, Johannes Schetelig, Marc Schmitz

https://doi.org/10.3324/haematol.2017.167312

Comment

Pseudo-monoclonal gammopathy: a report of four cases (575 Online Views)

Majd D. Jawad, Ronald S. Go, Thomas E. Witzig, Joseph R. Mikhael, Aishwarya Ravindran, David L. Murrray

https://doi.org/10.3324/haematol.2017.171694