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April, 2010
No. 95 (4)

Editorials

Paroxysmal nocturnal hemoglobinuria and eculizumab (2744 Online Views)

Lucio Luzzatto, Antonio Maria Risitano, Rosario Notaro

https://doi.org/10.3324/haematol.2009.017848

Molecular basis and clonal evolution of myeloproliferative neoplasms (1101 Online Views)

Roland Jäger, Robert Kralovics

https://doi.org/10.3324/haematol.2009.019570

Molecular and alternative methods for diagnosis of acute myeloid leukemia with mutated NPM1: flexibility may help (2322 Online Views)

Brunangelo Falini, Maria Paola Martelli, Stefano A. Pileri, Cristina Mecucci

https://doi.org/10.3324/haematol.2009.017822

Molecular basis of familial hemophagocytic lymphohistiocytosis (839 Online Views)

Valentina Cetica, Daniela Pende, Gillian M. Griffiths, Maurizio Aricò

https://doi.org/10.3324/haematol.2009.019562

Splenic marginal zone lymphoma: hydra with many heads? (1205 Online Views)

Luca Arcaini, Marco Paulli

https://doi.org/10.3324/haematol.2009.021576

Review Articles

Can antigen-specific regulatory T cells protect against graft versus host disease and spare anti-malignancy alloresponse? (878 Online Views)

Joseph Pidala, Claudio Anasetti

https://doi.org/10.3324/haematol.2009.015818

Articles

Hematopoietic stem cells in co-culture with mesenchymal stromal cells - modeling the niche compartments in vitro (4475 Online Views)

Duohui Jing, Ana-Violeta Fonseca, Nael Alakel, Fernando A. Fierro, Katrin Muller, Martin Bornhauser, Gerhard Ehninger, Denis Corbeil, Rainer Ordemann

https://doi.org/10.3324/haematol.2009.010736

The Southern French registry of genetic hemochromatosis: a tool for determining clinical prevalence of the disorder and genotype penetrance (834 Online Views)

Patricia Aguilar-Martinez, Michael Bismuth, François Blanc, Pierre Blanc, Severine Cunat, Olivier Dereure, Pierre Dujols, Muriel Giansily-Blaizot, Christian Jorgensen, Amadou Konate, Dominique Larrey, Alain Le Quellec, Thibault Mura, Isabelle Raingeard, Jeanne Ramos, Eric Renard, Florence Rousseau, Jean-François Schved, Marie-Christine Picot

https://doi.org/10.3324/haematol.2009.014431

Tailoring iron chelation by iron intake and serum ferritin: the prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemias (2280 Online Views)

Maria Domenica Cappellini, John Porter, Amal El-Beshlawy, Chi-Kong Li, John F. Seymour, Mohsen Elalfy, Norbert Gattermann, Stéphane Giraudier, Jong-Wook Lee, Lee Lee Chan, Kai-Hsin Lin, Christian Rose, Ali Taher, Swee Lay Thein, Vip Viprakasit, Dany Habr, Gabor Domokos, Bernard Roubert, Antonis Kattamis

https://doi.org/10.3324/haematol.2009.014696

Eculizumab prevents intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria and unmasks low-level extravascular hemolysis occurring through C3 opsonization (2686 Online Views)

Anita Hill, Russell P. Rother, Louise Arnold, Richard Kelly, Matthew J. Cullen, Stephen J. Richards, Peter Hillmen

https://doi.org/10.3324/haematol.2009.007229

Evaluation of hemostasis and endothelial function in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab (902 Online Views)

Dominique Helley, Régis Peffault de Latour, Raphaël Porcher, Celso Arrais Rodrigues, Isabelle Galy-Fauroux, Jeanne Matheron, Arnaud Duval, Jean-François Schved, Anne-Marie Fischer, Gérard Socié

https://doi.org/10.3324/haematol.2009.016121

Impact of additional chromosomal aberrations and BCR-ABL kinase domain mutations on the response to nilotinib in Philadelphia chromosome-positive chronic myeloid leukemia (847 Online Views)

Theo D. Kim, Seval Türkmen, Michaela Schwarz, Gökben Koca, Hendrik Nogai, Christiane Bommer, Bernd Dörken, Peter Daniel, Philipp le Coutre

https://doi.org/10.3324/haematol.2009.014712

Outcome after relapse of acute lymphoblastic leukemia in adult patients included in four consecutive risk-adapted trials by the PETHEMA Study Group (3367 Online Views)

Albert Oriol, Susana Vives, Jesús-María Hernández-Rivas, Mar Tormo, Inmaculada Heras, Concepción Rivas, Concepción Bethencourt, Federico Moscardó, Javier Bueno, Carlos Grande, Eloy del Potro, Ramon Guardia, Salut Brunet, Juan Bergua, Teresa Bernal, Maria-José Moreno, Carlota Calvo, Pilar Bastida, Evarist Feliu, Josep-Maria Ribera

https://doi.org/10.3324/haematol.2009.014274

Increased MYC gene copy number correlates with increased mRNA levels in diffuse large B-cell lymphoma (981 Online Views)

Christopher J. Stasik, Hiroaki Nitta, Wenjun Zhang, Charles H. Mosher, James R. Cook, Raymond R. Tubbs, Joseph M. Unger, Tracy A. Brooks, Daniel O. Persky, Sarah T. Wilkinson, Thomas M. Grogan, Lisa M. Rimsza

https://doi.org/10.3324/haematol.2009.012864

CD5 expression identifies a subset of splenic marginal zone lymphomas with higher lymphocytosis: a clinico-pathological, cytogenetic and molecular study of 24 cases (2559 Online Views)

Lucile Baseggio, Alexandra Traverse-Glehen, Florence Petinataud, Evelyne Callet-Bauchu, Françoise Berger, Martine Ffrench, Chantal Marie Couris, Catherine Thieblemont, Dominique Morel, Bertrand Coiffier, Gilles Salles, Pascale Felman

https://doi.org/10.3324/haematol.2009.011049

Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma (1618 Online Views)

Magdalena B. Wozniak, Raquel Villuendas, James R. Bischoff, Carmen Blanco Aparicio, Juan F. Martínez Leal, Paloma de La Cueva, Ma Elena Rodriguez, Beatriz Herreros, Daniel Martin-Perez, Maria I. Longo, Marta Herrera, Miguel Á. Piris, Pablo L Ortiz-Romero

https://doi.org/10.3324/haematol.2009.013870

UNC13D is the predominant causative gene with recurrent splicing mutations in Korean patients with familial hemophagocytic lymphohistiocytosis (1329 Online Views)

Hoi Soo Yoon, Hee-Jin Kim, Keon-Hee Yoo, Ki-Woong Sung, Hong-Hoe Koo, Hyoung Jin Kang, Hee Young Shin, Hyo Seop Ahn, Ji-Yoon Kim, Young-Tak Lim, Keun-Wook Bae, Ki-O Lee, Ji-Sook Shin, Seung-Tae Lee, Hae-Sun Chung, Sun-Hee Kim, Chan-Jeoung Park, Hyun-Sook Chi, Ho-Joon Im, Jong Jin Seo

https://doi.org/10.3324/haematol.2009.016949

Myelin protein zero is naturally processed in the B cells of monoclonal gammopathy of undetermined significance of immunoglobulin M isotype: aberrant triggering of a patient’s T cells (646 Online Views)

Eva Hellqvist, Maria Kvarnström, Anita Söderberg, Magnus Vrethem, Jan Ernerudh, Anders Rosén

https://doi.org/10.3324/haematol.2009.015123

Changes in the use of hematopoietic stem cell transplantation: a model for diffusion of medical technology (984 Online Views)

Alois Gratwohl, Alvin Schwendener, Helen Baldomero, Michael Gratwohl, Jane Apperley, Dietger Niederwieser, Karl Frauendorfer

https://doi.org/10.3324/haematol.2009.015586

Invasive aspergillosis in patients with acute myeloid leukemia: a SEIFEM-2008 registry study (2676 Online Views)

Livio Pagano, Morena Caira, Anna Candoni, Massimo Offidani, Bruno Martino, Giorgina Specchia, Domenico Pastore, Marta Stanzani, Chiara Cattaneo, Rosa Fanci, Cecilia Caramatti, Fausto Rossini, Mario Luppi, Leonardo Potenza, Felicetto Ferrara, Maria Enza Mitra, Rafaela Maria Fadda, Rosangela Invernizzi, Teresa Aloisi, Marco Picardi, Alessandro Bonini, Adriana Vacca, Anna Chierichini, Lorella Melillo, Chiara de Waure, Luana Fianchi, Marta Riva, Giuseppe Leone, Franco Aversa, Annamaria Nosari

https://doi.org/10.3324/haematol.2009.012054

CD271 antigen defines a subset of multipotent stromal cells with immunosuppressive and lymphohematopoietic engraftment-promoting properties (1827 Online Views)

Selim Kuçi, Zyrafete Kuçi, Hermann Kreyenberg, Erika Deak, Kathrin Pütsch, Sabine Huenecke, Chandrasekhar Amara, Stefanie Koller, Eva Rettinger, Manuel Grez, Ulrike Koehl, Hatixhe Latifi-Pupovci, Reinhard Henschler, Torsten Tonn, Dorothee von Laer, Thomas Klingebiel, Peter Bader

https://doi.org/10.3324/haematol.2009.015065

Brief Reports

High-resolution single-nucleotide polymorphism array-profiling in myeloproliferative neoplasms identifies novel genomic aberrations (777 Online Views)

Frank Stegelmann, Lars Bullinger, Martin Griesshammer, Karlheinz Holzmann, Marianne Habdank, Susanne Kuhn, Carmen Maile, Stefanie Schauer, Hartmut Döhner, Konstanze Döhner

https://doi.org/10.3324/haematol.2009.013623

Can cytoplasmic nucleophosmin be detected by immunocytochemical staining of cell smears in acute myeloid leukemia? (474 Online Views)

Göran Mattsson, Susan H. Turner, Jacqueline Cordell, David J.P. Ferguson, Anna Schuh, Lizz F. Grimwade, Anthony J. Bench, Olga K. Weinberg, Teresa Marafioti, Tracy I. George, Daniel A. Arber, Wendy N. Erber, David Y. Mason

https://doi.org/10.3324/haematol.2009.011817

Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and γ-secretase inhibitors (836 Online Views)

Ana Silva, Patrícia Y. Jotta, André B. Silveira, Daniel Ribeiro, Silvia R. Brandalise, J. Andrés Yunes, João T. Barata

https://doi.org/10.3324/haematol.2009.011999

Flow minimal residual disease monitoring of candidate leukemic stem cells defined by the immunophenotype, CD34+CD38lowCD19+ in B-lineage childhood acute lymphoblastic leukemia (689 Online Views)

Kerrie Wilson, Marian Case, Lynne Minto, Simon Bailey, Nick Bown, Jenny Jesson, Sarah Lawson, Josef Vormoor, Julie Irving

https://doi.org/10.3324/haematol.2009.011726

Letters to the Editor

Similar favorable outcome of pegfilgrastim overdose in patients with different age and underlying disease (433 Online Views)

Carlo Dufour, Barbara Cappelli, Michaela Calvillo, Francesca Fioredda, Rossella Tonelli, Roberto Crocchiolo

https://doi.org/10.3324/haematol.2009.018333
Disorders of Iron Metabolism

Homozygous deletion of HFE is the common cause of hemochromatosis in Sardinia (483 Online Views)

Gérald Le Gac, Rita Congiu, Isabelle Gourlaouen, Milena Cau, Claude Férec, Maria Antonietta Melis

https://doi.org/10.3324/haematol.2009.016816

HAMP promoter mutation nc.-153C>T in non p.C282Y homozygous patients with iron overload (443 Online Views)

Patricia Aguilar-Martinez, Muriel Giansily-Blaizot, Michael Bismuth, Séverine Cunat, Hélène Igual, Jean François Schved

https://doi.org/10.3324/haematol.2009.018028

A novel XIAP mutation in a Japanese boy with recurrent pancytopenia and splenomegaly (618 Online Views)

Meina Zhao, Hirokazu Kanegane, Kazutaka Ouchi, Toshihiko Imamura, Sylvain Latour, Toshio Miyawaki

https://doi.org/10.3324/haematol.2009.018010

Mutations of the Shwachman-Bodian-Diamond syndrome gene in patients presenting with refractory cytopenia – do we have to screen? (950 Online Views)

Axel Karow, Christian Flotho, Michaela Schneider, Manfred Fliegauf, Charlotte M. Niemeyer

https://doi.org/10.3324/haematol.2009.015008

Enhanced sensitivity of flow cytometry for routine assessment of minimal residual disease (738 Online Views)

Esther Domingo, Cristina Moreno, Alfonso Sánchez-Ibarrola, Carlos Panizo, José Antonio Páramo, Juana Merino

https://doi.org/10.3324/haematol.2009.018911
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