July, 2008
No. 93 (7)

Editorials

Articles

Fluorescence in situ hybridization improves the detection of 5q31 deletion in myelodysplastic syndromes without cytogenetic evidence of 5q-

Mar Mallo, Leonor Arenillas, Blanca Espinet, Marta Salido, Jesús Mª Hernández, Eva Lumbreras, Mónica del Rey, Eva Arranz, Soraya Ramiro, Patricia Font, Olga González, Mónica Renedo, José Cervera, Esperanza Such, Guillermo F. Sanz, Elisa Luño, Carmen Sanzo, Miriam González, María José Calasanz, José Mayans, Carlos García-Ballesteros, Victoria Amigo, Rosa Collado, Isabel Oliver, Félix Carbonell, Encarna Bureo, Andrés Insunza, Lucrecia Yañez, María José Muruzabal, Elena Gómez-Beltrán, Rafael Andreu, Pilar León, Valle Gómez, Ángeles Sanz, Natalia Casasola, Esperanza Moreno, Adrián Alegre, María Luisa Martín, Carmen Pedro, Sergi Serrano, Lourdes Florensa, Francesc Solé

https://doi.org/10.3324/haematol.13012

Prognostic impact of genetic characterization in the GIMEMA LAM99P multicenter study for newly diagnosed acute myeloid leukemia

Francesco Lo-Coco, Antonio Cuneo, Fabrizio Pane, Daniela Cilloni, Daniela Diverio, Marco Mancini, Nicoletta Testoni, Antonella Bardi, Barbara Izzo, Niccolò Bolli, Roberta La Starza, Paola Fazi, Simona Iacobelli, Alfonso Piciocchi, Marco Vignetti, Sergio Amadori, Franco Mandelli, Pier Giuseppe Pelicci, Cristina Mecucci, Brunangelo Falini, Giuseppe Sagliofor the Acute Leukemia Working Party of the GIMEMA group, Giuseppe Sagliofor the Acute Leukemia Working Party of the GIMEMA group

https://doi.org/10.3324/haematol.12004

M4 acute myeloid leukemia: the role of eosinophilia and cytogenetics in treatment response and survival. The GIMEMA experience

Alessandro Pulsoni, Simona Iacobelli, Massimo Bernardi, Marco Borgia, Andrea Camera, Nicola Cantore, Francesco Di Raimondo, Paola Fazi, Felicetto Ferrara, Franco Leoni, Vincenzo Liso, Marco Mancini, Filippo Marmont, Angela Matturro, Luca Maurillo, Lorella Melillo, Giovanna Meloni, Salvo Mirto, Giorgina Specchia, Caterina Giovanna Valentini, Adriano Venditti, Giuseppe Leone, Robin Foà, Franco Mandelli, Livio Pagano

https://doi.org/10.3324/haematol.11889

Gene expression analysis provides a potential rationale for revising the histological grading of follicular lymphomas

Pier Paolo Piccaluga, Andrea Califano, Ulf Klein, Claudio Agostinelli, Beatriz Bellosillo, Eva Gimeno, Sergi Serrano, Francisco Solè, Yonghui Zang, Brunangelo Falini, Pier Luigi Zinzani, Stefano A. Pileri

https://doi.org/10.3324/haematol.12754

The effect of FK506 on transforming growth factor β signaling and apoptosis in chronic lymphocytic leukemia B cells

Simona Romano, Maria Mallardo, Federico Chiurazzi, Rita Bisogni, Anna D’Angelillo, Raffaele Liuzzi, Giovanna Compare, Maria Fiammetta Romano

https://doi.org/10.3324/haematol.12402

A bioluminescence imaging based in vivo model for preclinical testing of novel cellular immunotherapy strategies to improve the graft-versus-myeloma effect

Henk Rozemuller, Ellen van der Spek, Lijnie H. Bogers-Boer, Mieke C. Zwart, Vivienne Verweij, Maarten Emmelot, Richard W. Groen, Robbert Spaapen, Andries C. Bloem, Henk M. Lokhorst, Tuna Mutis, Anton C. Martens

https://doi.org/10.3324/haematol.12349

Granulocyte concentrates: prolonged functional capacity during storage in the presence of phenotypic changes

Agata Drewniak, Jaap-Jan Boelens, Hans Vrielink, Anton T.J. Tool, Marrie C.A. Bruin, Marry van den Heuvel-Eibrink, Lynne Ball, Marianne D. van de Wetering, Dirk Roos, Taco W. Kuijpers

https://doi.org/10.3324/haematol.12489

Influence of sickle cell disease and treatment with hydroxyurea on sperm parameters and fertility of human males

Isabelle Berthaut, Geoffroy Guignedoux, Frederique Kirsch-Noir, Vanina de Larouziere, Celia Ravel, Dora Bachir, Frédéric Galactéros, Pierre-Yves Ancel, Jean-Marie Kunstmann, Laurence Levy, Pierre Jouannet, Robert Girot, Jacqueline Mandelbaum

https://doi.org/10.3324/haematol.11515

Genome-wide analysis of copy number changes and loss of heterozygosity in myelodysplastic syndrome with del(5q) using high-density single nucleotide polymorphism arrays

Li Wang, Carrie Fidler, Nandita Nadig, Aristoteles Giagounidis, Matteo G. Della Porta, Luca Malcovati, Sally Killick, Norbert Gattermann, Carlo Aul, Jacqueline Boultwood, James S. Wainscoat

https://doi.org/10.3324/haematol.12603

Letters to the Editor

No evidence of cardiac iron in 20 never- or minimally-transfused patients with thalassemia intermedia

Raffaella Origa, Susanna Barella, Giovanni Maria Argiolas, Patrizio Bina, Annalisa Agus, Renzo Galanello

https://doi.org/10.3324/haematol.12484

Myeloproliferative Disorders

Low-dose thalidomide in myelofibrosis

Robert Weinkove, John T. Reilly, Mary Frances McMullin, Natasha J. Curtin, Deepti Radia, Claire N. Harrison

https://doi.org/10.3324/haematol.12416

Chronic Myeloid Leukemia

Acute Myeloid Leukemia

Expression of the nuclear oncogene Ski in patients with acute myeloid leukemia treated with all-trans retinoic acid

Sabine Teichler, Richard F. Schlenk, Konstantin Strauch, Nicole M. Hagner, Markus Ritter, Andreas Neubauer

https://doi.org/10.3324/haematol.12003

NOTCH2 mutations in marginal zone lymphoma

Gunhild Trøen, Iwona Wlodarska, Abdirashid Warsame, Silvia Hernández Llodrà, Christiane De Wolf-Peeters, Jan Delabie

https://doi.org/10.3324/haematol.11635

Monoclonal Gammopathies

Chronic Lymphocytic Leukemia

A possible role for low-dose cyclosporine in refractory immune thrombocytopenic purpura

Giovanni Emilia, Mario Luppi, Monica Morselli, Fabio Forghieri, Leonardo Potenza, Giuseppe Torelli

https://doi.org/10.3324/haematol.12741

IgM anti-protein S antibodies as a risk factor for venous thrombosis

Montserrat Borrell, Isabel Tirado, José Mateo, Artur Oliver, Amparo Santamaría, Jordi Fontcuberta

https://doi.org/10.3324/haematol.12575

Antiplatelet drugs and risk of venous thromboembolism: results from the EDITH case-control study

Karine Lacut, Jantien van der Maaten, Grégoire Le Gal, Géraldine Cornily, Dominique Mottier, Emmanuel Oger

https://doi.org/10.3324/haematol.12331

Persistent bone disease in adult type 1 Gaucher disease despite increasing doses of enzyme replacement therapy

Maaike de Fost, Carel J.M. van Noesel, Johannes M.F.G. Aerts, Mario Maas, Ruud G. Pöll, Carla E.M. Hollak

https://doi.org/10.3324/haematol.12651

Online Only Articles

Brief Reports

A novel heterozygous HIF2AM535I mutation reinforces the role of oxygen sensing pathway disturbances in the pathogenesis of familial erythrocytosis

Maurizio Martini, Luciana Teofili, Tonia Cenci, Fiorina Giona, Lorenza Torti, Massimiliano Rea, Robin Foà, Giuseppe Leone, Luigi Maria Larocca

https://doi.org/10.3324/haematol.13210

A study of 36 unrelated cases with pure erythrocytosis revealed three new mutations in the erythropoietin receptor gene

Maha Al-Sheikh, Elodie Mazurier, Betty Gardie, Nicole Casadevall, Frédéric Galactéros, Michel Goossens, Henri Wajcman, Claude Préhu, Valérie Ugo

https://doi.org/10.3324/haematol.12260

Acute Myeloid Leukemia

Molecular characterization of the MLL-SEPT6 fusion gene in acute myeloid leukemia: identification of novel fusion transcripts and cloning of genomic breakpoint junctions

Nuno Cerveira, Francesca Micci, Joana Santos, Manuela Pinheiro, Cecília Correia, Susana Lisboa, Susana Bizarro, Lucília Norton, Anders Glomstein, Ann E. Åsberg, Sverre Heim, Manuel R. Teixeira

https://doi.org/10.3324/haematol.12594

Transcriptional activation of the cardiac homeobox gene CSX1/NKX2-5 in a B-cell chronic lymphoproliferative disorder

Xinying Su, Véronique Della-Valle, Eric Delabesse, Zahia Azgui, Roland Berger, Hélène Merle-Béral, Olivier A Bernard, Florence Nguyen-Khac

https://doi.org/10.3324/haematol.12595

Mutations affecting mRNA splicing are the most common molecular defect in patients with familial hemophagocytic lymphohistiocytosis type 3

Alessandra Santoro, Sonia Cannella, Antonino Trizzino, Giuseppa Bruno, Carmen De Fusco, Luigi D. Notarangelo, Daniela Pende, Gillian M. Griffiths, Maurizio Aricò

https://doi.org/10.3324/haematol.12622

Disorders of Hemostasis

Severe and moderate hemophilia A: identification of 38 new genetic alterations

Pilar Casaña, Noelia Cabrera, Ana Rosa Cid, Saturnino Haya, Magdalena Beneyto, Carmen Espinós, Vicente Cortina, Maria Angeles Dasí, Josè Antonio Aznar

https://doi.org/10.3324/haematol.12344