Association of estrogen receptor-alpha genepolymorphisms with venous thrombosis

Abstract

XbaI and PvuII polymorphisms of the estrogen receptor-alpha gene (ERalpha) have been associated with several multifactorial diseases. We studied the distribution of ERalpha polymorphisms in patients with deep vein thrombosis. PvuII PP and XbaI XX genotypes may be associated with an approximately 2-fold increased DVT risk of deep vein thrombosis in men.