AbstractWe studied the effects of varying and steady-state concentrations of arsenic trioxide (As2O3) on apoptosis and differentiation of several cell lines in vitro. We also studied the same effects of fluctuating vs constant concentrations of As2O3 in vivo in patients treated with daily 3-hour fast infusions or daily slow, continuous infusions. Intracellular concentrations of arsenic and apoptosis rate were higher whereas differentiation was reduced in cells exposed to constant concentrations of As2O3.
Figures & Tables
Vol. 90 No. 9 (2005): September, 2005 : Comparative Studies
Ferrata Storti Foundation, Pavia, Italy
Statistics from Altmetric.com