High-dose granulocyte colony-stimulating factor mobilizes a higher proportion of early CD34(+) CD33(-) hemopoietic progenitors in children receiving treatment for solid tumors

Abstract

A relationship between dose of granulocyte colony-stimulating factor (G-CSF) and maturational stage of the progenitors mobilized in healthy adult donors has been suggested. In this study we characterize the progenitors mobilized by 2 different dosages of G-CSF in children receiving autologous grafts after intensive treatment for solid tumors.