Malarial anemia involves destruction of parasitized and non-parasitized red blood cells and dyserythropoiesis. Malarial pigment, hemozoin (HZ), is possibly implicated in dyserythropoiesis. We show that supernatants of HZ and HZ-fed-monocytes, and 4-hydroxynonenal generated by them, inhibited progenitor growth.
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Vol. 89 No. 4 (2004): April, 2004 : Letters to the Editor
G Giribaldi, D Ulliers, E Schwarzer, I Roberts, W Piacibello, P Arese. Hemozoin- and 4-hydroxynonenal-mediated inhibition of erythropoiesis. Possible role in malarial dyserythropoiesis and anemia. Haematologica 2004; 89(4):492-493; https://doi.org/10.3324/%x.
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