CURRENT ISSUE
May, 2026
No. 111 (5)
2024 Impact Factor: 7.9
2024 Journal Citation Indicator: 1.9
2024 CiteScore: 11.3
2024 Journal Citation Indicator: 1.9
2024 CiteScore: 11.3
EDITOR'S PICKS
Clonal hematopoiesis Review Series – from biology to clinical management
Introduction to the Review Series. Clonal hematopoiesis review series – from biology to clinical management
Clonal hematopoiesis and its progression to myeloid neoplasms: insights into risk, biology, and therapeutic strategies
What’s hidden in plain sight? Impact of clonal hematopoiesis on the risk and progression of nonhematologic cancers
Novel and emerging therapeutic strategies for clonal hematopoiesis
Clonal hematopoiesis driver mutations: molecular mechanisms and clinical implications - inclusive fitness of pre-leukemic hematopoietic stem and progenitor cells through pro-inflammatory features of their progeny
Clinical decisions in clonal hematopoiesis: a contemporary review for clinicians
ARTICLES IN THREE SENTENCES
Article
Neurodegenerative Langerhans cell histiocytosis: long-term follow-up of 63 patients from the Italian Registry
Neurodegenerative Langerhans cell histiocytosis (ND-LCH) is characterized by progressive neurological impairment and poorly defined long-term outcomes. In their study, Trambusti and colleagues analyzed data from 63 patients with ND-LCH enrolled in the Italian Registry. They found that ND-LCH follows a heterogeneous but often progressive course underscoring the need for early recognition and standardized therapeutic strategies.
Article
Ethnicity affects relapse-free survival in immunemediated thrombotic thrombocytopenic purpura
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a thrombotic microangiopathy with heterogeneous risk of relapse. Weisinger and colleagues evaluated the impact of ethnicity on relapse-free survival in a cohort of patients with iTTP from the registry of the French National Thrombotic Microangiopathy Reference Center. They found that ethnicity significantly influences relapse risk, highlighting the importance of considering ethnicity in risk stratification and long-term management of iTTP.
Letter
Comparative effectiveness of immunotherapy alone or with chemotherapy as first-line treatment for marginal zone lymphoma
Marginal zone lymphoma (MZL) is an indolent B-cell lymphoma for which optimal first-line treatment remains debated. In this study, the authors performed a comparative effectiveness analysis of first-line immunotherapy versus immunochemotherapy using real-world clinical data. They found that immunochemotherapy improved response rates and disease control in selected patients, while immunotherapy alone remained an effective option for less aggressive disease.
Letter
Multi-omics analysis reveals a unique epigenetic signature in MYD88 wild-type Waldenström macroglobulinemia
Waldenström macroglobulinemia (WM) is typically driven by MYD88 mutations, while MYD88 wild-type cases represent a less well-characterized subgroup. In this study, the authors performed integrated multi-omics profiling to define the molecular features of MYD88 wild-type WM. They identified a unique epigenetic landscape with distinct regulatory programs, supporting the existence of a biologically separate subtype with potential diagnostic and therapeutic implications.
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