Renal survival in AL amyloidosis depends on several histopathological and laboratory parameters. At present, two independent staging systems categorize patients into three renal stages and predict outcome. Rauf and colleagues propose a revised four-stage renal stratification model outperforming previous models for predicting renal outcomes.

Mutations in the PTPN11 gene, which encodes a phosphatase involved in signaling pathways, occur in various hematologic disorders. Bazinet and colleagues investigated the role of PTPN11 mutations in a retrospective cohort of more than 1,700 patients with myelodysplastic syndromes (MDS). The findings demonstrate that PTPN11 mutations are associated with a rare but particularly aggressive subset of MDS, leading to poorer prognosis and treatment responses.