ISSUE
February, 2022
No. 107 (2)
2024 Impact Factor: 7.9
2024 Journal Citation Indicator: 1.9
2024 CiteScore: 11.3
2024 Journal Citation Indicator: 1.9
2024 CiteScore: 11.3
EDITOR'S PICKS
ARTICLES IN THREE SENTENCES
Article
Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity
Hematopoietic stem cells (HSC) maintain blood homeostasis and show an age-related decline in overall function. This study characterized age-related changes in human and murine HSC. The data reported support the possibility of rejuvenating the function of aged human HSC by inhibiting the age-related increase in Cdc42 activity.
Article
Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34+ cord blood hematopoietic stem cells using a clinically applicable lentiviral vector
Twenty-five percent of patients with Diamond-Blackfan anemia (DBA) have mutations in a gene encoding ribosomal protein S19 (RPS19). The authors of this study developed a single gene, self-inactivating lentiviral vector containing human RPS19 cDNA. It was used for the successful treatment of Rps19-deficient DBA in a mouse model.
Article
APR-246 induces early cell death by ferroptosis in acute myeloid leukemia
APR-246 is a new therapeutic agent that targets mutated p53 proteins in acute myeloid leukemia (AML) and myelodysplastic syndromes. APR-246 can also induce p53-independent cell death in cancer. The authors of this study demonstrated that cell death promoted by APR-246 in AML is due to induction of ferroptosis, which may represent a new therapeutic target in AML.
Article
Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis
The diagnosis of angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma with T follicular helper phenotype is challenging. This study showed that RHOA Gly17Val mutation analysis is valuable in the early detection of these disorders.
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