This study in humans and mice found extensive damage, structural changes, and dysfunction of the vasculature during acute graft-versus-host disease (GvHD). Severe endothelial damage and reduced endothelial pericyte coverage were observed in murine experimental acute GvHD. The endothelium-protective sildenafil improved survival and reduced target organ damage in mice.

The authors used combinatorial drug screening to identify synergistic combination partners to enhance the efficacy of venetoclax in patients with T-prolymphocytic leukemia. In vitro studies demonstrated that the combination with ibrutinib increased cell priming for apoptosis and Bcl-2 dependence. The combination produced clinical responses in two heavily pretreated patients. A large clinical study is ongoing.