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November, 2012
No. 97 (11)

Editorials

Extramedullary involvement in multiple myeloma (1096 Online Views)

Joan Bladé, Carlos Fernández de Larrea, Laura Rosiñol

https://doi.org/10.3324/haematol.2012.078519

A novel combination therapy approach for the treatment of acute myeloid leukemia: the multi-kinase inhibitor sorafenib and the HDM2 inhibitor nutlin-3 (248 Online Views)

Ellen Weisberg, Martin Sattler

https://doi.org/10.3324/haematol.2012.078451

Review Articles

Genetic modification of human T lymphocytes for the treatment of hematologic malignancies (1280 Online Views)

Valentina Hoyos, Barbara Savoldo, Gianpietro Dotti

https://doi.org/10.3324/haematol.2012.064303

Articles

The role of WDR5 in silencing human fetal globin gene expression (1095 Online Views)

Zhen Xu, Yinghong He, Junyi Ju, Gerhard Rank, Loretta Cerruti, Chi Ma, Richard J. Simpson, Robert L. Moritz, Stephen M. Jane, Quan Zhao

https://doi.org/10.3324/haematol.2012.061937

Late stage erythroid precursor production is impaired in mice with chronic inflammation (813 Online Views)

Olivier D. Prince, Jacqueline M. Langdon, Andrew J. Layman, Ian C. Prince, Miguel Sabogal, Howard H. Mak, Alan E. Berger, Chris Cheadle, Francis J. Chrest, Qilu Yu, Nancy C. Andrews, Qian-Li Xue, Curt I. Civin, Jeremy D. Walston, Cindy N. Roy

https://doi.org/10.3324/haematol.2011.053397

Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes (1282 Online Views)

Alessandra Balduini, Christian Andrea Di Buduo, Alessandro Malara, Anna Lecchi, Paola Rebuzzini, Manuela Currao, Isabella Pallotta, Joseph A. Jakubowski, Marco Cattaneo

https://doi.org/10.3324/haematol.2011.059212

Allogeneic stem cell transplantation in paroxysmal nocturnal hemoglobinuria (1263 Online Views)

Régis Peffault de Latour, Hubert Schrezenmeier, Andrea Bacigalupo, Didier Blaise, Carmino A. de Souza, Stephane Vigouroux, Roelf Willemze, Louis Terriou, Andre Tichelli, Mohamad Mohty, Sophie de Guibert, Judith C. Marsh, Jakob Passweg, Jean Yves Mary, Gerard Socié

https://doi.org/10.3324/haematol.2012.062828

Loss of endothelial thrombomodulin predicts response to steroid therapy and survival in acute intestinal graft-versus-host disease (871 Online Views)

Mindaugas Andrulis, 1 Sascha Dietrich, Thomas Longerich, Ronald Koschny, Maria Burian, Annette Schmitt-Gräf, Peter Schirmacher, Anthony D. Ho, Peter Dreger, Thomas Luft

https://doi.org/10.3324/haematol.2011.061051

Depletion of T regulatory cells through selection of CD127-positive cells results in a population enriched in memory T cells: implications for anti-tumor cell therapy (975 Online Views)

Soumia Touil, Michelle Rosenzwajg, Dan Avi Landau, Philippe Le Corvoisier, Charlotte Frédéric, David Klatzmann, Sébastien Maury, José L. Cohen

https://doi.org/10.3324/haematol.2011.056374

Anti-CD20 IgA can protect mice against lymphoma development: evaluation of the direct impact of IgA and cytotoxic effector recruitment on CD20 target cells (859 Online Views)

Virginie Pascal, Brice Laffleur, Arnaud Debin, Armelle Cuvillier, Marjolein van Egmond, Daniel Drocourt, Laurent Imbertie, Céline Pangault, Karin Tarte, Gérard Tiraby, Michel Cogné

https://doi.org/10.3324/haematol.2011.061408

Hepcidin demonstrates a biphasic association with anemia in acute Plasmodium falciparum malaria (907 Online Views)

Climent Casals-Pascual, Honglei Huang, Samira Lakhal-Littleton, Marie L. Thezenas, Oscar Kai, Charles R.J.C. Newton, David J. Roberts

https://doi.org/10.3324/haematol.2012.065854

Increased angiogenesis and enhanced bone formation in patients with IgM monoclonal gammopathy and urticarial skin rash: new insight into the biology of Schnitzler syndrome (443 Online Views)

Evangelos Terpos, Bouchra Asli, Dimitrios Christoulas, Jean-Claude Brouet, Efstathios Kastritis, Michel Rybojad, Djaouida Bengoufa, Meletios A. Dimopoulos, Jean Paul Fermand

https://doi.org/10.3324/haematol.2012.067306

Red cell mass measurement in patients with clinically suspected diagnosis of polycythemia vera or essential thrombocythemia (1955 Online Views)

Alberto Alvarez-Larrán, Agueda Ancochea, Anna Angona, Carme Pedro, Francesc García-Pallarols, Luz Martínez-Avilés, Beatriz Bellosillo, Carlos Besses

https://doi.org/10.3324/haematol.2012.067348

Clinical, immunophenotypic, cytogenetic, and molecular genetic features in 117 adult patients with mixed-phenotype acute leukemia defined by WHO-2008 classification (1561 Online Views)

Lingzhi Yan, Nana Ping, Mingqing Zhu, Aining Sun, Yongquan Xue, Changgeng Ruan, Hans G. Drexler, Roderick A. F. MacLeod, Depei Wu, Suning Chen

https://doi.org/10.3324/haematol.2012.064485

MicroRNA-125b transforms myeloid cell lines by repressing multiple mRNA (869 Online Views)

Marina Bousquet, Diu Nguyen, Cynthia Chen, Lauren Shields, Harvey F. Lodish

https://doi.org/10.3324/haematol.2011.061515

The sorafenib plus nutlin-3 combination promotes synergistic cytotoxicity in acute myeloid leukemic cells irrespectively of FLT3 and p53 status (1163 Online Views)

Giorgio Zauli, Claudio Celeghini, Elisabetta Melloni, Rebecca Voltan, Manuele Ongari, Mario Tiribelli, Maria Grazia di Iasio, Francesco Lanza, Paola Secchiero

https://doi.org/10.3324/haematol.2012.062083

Randomized phase II study of two schedules of flavopiridol given as timed sequential therapy with cytosine arabinoside and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia (746 Online Views)

Judith E. Karp, Elizabeth Garrett-Mayer, Elihu H. Estey, Michelle A. Rudek, B. Douglas Smith, Jacqueline M. Greer, D. Michelle Drye, Karen Mackey, Kathleen Shannon Dorcy, Steven D. Gore, Mark J. Levis, Michael A. McDevitt, Hetty E. Carraway, Keith W. Pratz, Douglas E. Gladstone, Margaret M. Showel, Megan Othus, L. Austin Doyle, John J. Wright, John M. Pagel

https://doi.org/10.3324/haematol.2012.062539

Excellent prognosis of late relapses of ETV6/RUNX1-positive childhood acute lymphoblastic leukemia: lessons from the FRALLE 93 protocol (1036 Online Views)

Virginie Gandemer, Sylvie Chevret, Arnaud Petit, Christiane Vermylen, Thierry Leblanc, Gérard Michel, Claudine Schmitt, Odile Lejars, Pascale Schneider, François Demeocq, Brigitte Bader-Meunier, Françoise Bernaudin, Yves Perel, Marie-Françoise Auclerc, Jean-Michel Cayuela, Guy Leverger, André Baruchel

https://doi.org/10.3324/haematol.2011.059584

Changes in magnetic resonance imaging before and after autologous stem cell transplantation correlate with response and survival in multiple myeloma (900 Online Views)

Jens Hillengass, Sofia Ayyaz, Kerstin Kilk, Marc-André Weber, Thomas Hielscher, Rajiv Shah, Dirk Hose, Stefan Delorme, Hartmut Goldschmidt, Kai Neben

https://doi.org/10.3324/haematol.2012.065359

Extramedullary disease portends poor prognosis in multiple myeloma and is over-represented in high-risk disease even in the era of novel agents (41708 Online Views)

Saad Z. Usmani, Christoph Heuck, Alan Mitchell, Jackie Szymonifka, Bijay Nair, Antje Hoering, Yazan Alsayed, Sarah Waheed, Sajjad Haider, Alejandro Restrepo, Frits Van Rhee, John Crowley, Bart Barlogie

https://doi.org/10.3324/haematol.2012.065698

Letters to the Editor

Atorvastatin reduces serum cholesterol and triglycerides with limited improvement in vascular function in adults with sickle cell anemia (771 Online Views)

Candice Bereal-Williams, Roberto F. Machado, Vicki McGowan, Amy Chi, Christian J. Hunter, Gregory J. Kato

https://doi.org/10.3324/haematol.2011.054957

Predictors and short-term outcomes of hyperleukocytosis in children with acute myeloid leukemia: a report from the Children's Oncology Group (652 Online Views)

Lillian Sung, Richard Aplenc, Todd A. Alonzo, Robert B. Gerbing, Alan S. Gamis, AAML0531/PHIS Group

https://doi.org/10.3324/haematol.2012.065490

The N676D and G697R mutations in the kinase domain of FLT3 confer resistance to the inhibitor AC220 (555 Online Views)

Daphnie Pauwels, Bram Sweron, Jan Cools

https://doi.org/10.3324/haematol.2012.069781

Hematology News

Do educated natural killer cells make the grade in treating acute myeloid leukemia? (304 Online Views)

Ronjon Chakraverty

https://doi.org/10.3324/haematol.2012.078717

Online Only Articles

The use of age-dependent D-dimer cut-off values to exclude deep vein thrombosis. Reply to “Using an age-dependent D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can be safely excluded”. Haematologica 2012;97(10):1507-13 (581 Online Views)

Angela D. Hamblin, Karen Cairns, David M. Keeling

https://doi.org/10.3324/haematol.2012.072231

Fc gamma receptor 3a genotype in follicular lymphoma: the end of the story? Reply to “Fc gamma receptor 3a genotype predicts overall survival in follicular lymphoma patients treated on SWOG trials with combined monoclonal antibody plus chemotherapy but not chemotherapy alone”. Haematologica. 2012;97(6):937-942 (136 Online Views)

Vít Procházka, Jana Gazdová, Tomáš Papajík

https://doi.org/10.3324/haematol.2012.071563

Reply to “Fc gamma receptor 3a genotype in follicular lymphoma: the end of the story?” Haematologica. 2012;97(11):e45 (225 Online Views)

Daniel O. Persky, David Dornan, Bryan H. Goldman, Rita M. Braziel, Richard I. Fisher, Michael LeBlanc, David G. Maloney, Oliver W. Press, Thomas P. Miller, Lisa M. Rimsza

https://doi.org/10.3324/haematol.2012.077461

Original Articles and Brief Reports

Hemorheological risk factors of acute chest syndrome and painful vaso-occlusive crisis in children with sickle cell disease (1181 Online Views)

Yann Lamarre, Marc Romana, Xavier Waltz, Marie-Laure Lalanne-Mistrih, Benoît Tressières, Lydia Divialle-Doumdo, Marie-Dominique Hardy-Dessources, Jens Vent-Schmidt, Marie Petras, Cedric Broquere, Frederic Maillard, Vanessa Tarer, Maryse Etienne-Julan, Philippe Connes

https://doi.org/10.3324/haematol.2012.066670

Allogeneic stem cell transplantation for advanced acute promyelocytic leukemia in the ATRA and ATO era (724 Online Views)

Safaa M. Ramadan, Ambra Di Veroli, Agnese Camboni, Massimo Breccia, Anna Paola Iori, Franco Aversa, Luca Cupelli, Cristina Papayannidis, Andrea Bacigalupo, William Arcese, Francesco Lo-Coco

https://doi.org/10.3324/haematol.2012.065714

Intensive chemotherapy with thiotepa, busulfan and cyclophosphamide and hematopoietic stem cell rescue in relapsed or refractory primary central nervous system lymphoma and intraocular lymphoma: a retrospective study of 79 cases (987 Online Views)

Carole Soussain, Sylvain Choquet, Emmanuelle Fourme, Daniel Delgadillo, Krimo Bouabdallah, Hervé Ghesquières, Gandhi Damaj, Brigitte Dupriez, Jacques Vargaftig, Alberto Gonzalez, Caroline Houillier, Luc Taillandier, Khê Hoang-Xuan, Véronique Leblond

https://doi.org/10.3324/haematol.2011.060434
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