Erratum to: “Extracellular vesicles mediate the communication between multiple myeloma and bone marrow microenvironment in a NOTCH dependent way”

In the representative panel of the osteoclast differentiation assay shown in Figure 5A,¹ the image displayed for the “RANKL” condition was incorrect due to an error during figure preparation. The correct representative image has now been provided. This correction does not affect the results or conclusions of the paper. The authors sincerely apologize for this error and for any inconvenience it may have caused.

Correct Figure 5.NOTCH2 contributes to the protumorigenic communication of multiple myeloma cell-released extracellular vesicles toward osteoclasts and endothelial cells. (A) The effect of MM-EV^SCR and MM-EV^N2KD collected from the osteoclastogenic cell line RPMI8226. The Raw264.7 cell line was treated with or without the osteoclastogenic RANKL (30 ng/mL), multiple myeloma cell-released extracellular vesicles (MM-EV) or control fresh medium (w/o EV). After 7 days TRAP-positive multinucleated cells (≥3 nuclei) were enumerated (TRAP-positive multinucleated cells are indicated by an arrow). Representative images are shown for each condition on the left (4x magnification); a graph on the right represents the mean value of the absolute number of TRAP-positive multinucleated cells +/- standard error of the mean. Statistical analysis by a one-way ANOVA with Tukey post hoc test; *P<0.05. (B) Tumor angiogenesis induced by MM-EV^SCR and MM-EV^N2KD. Tube formation assay performed for 13 hours with primary human pulmonary arterial cells (HPAEC) laid on a matrigel-coated support stimulated with MM-EV^SCR and MM-EV^N2KD collected from RPMI8226 and OPM2 cells or control fresh medium (w/o EV). The graphs show the mean values of areas and nodes (branch points) enumerated in 4 quadrants of the well +/- standard error of the mean. Statistical analysis was performed by ANOVA and Tukey post hoc test; *P<0.05; **P<0.01. Representative images are shown below for each condition (4x magnification).

Footnotes

• Received March 17, 2026
• Accepted March 17, 2026

Correspondence

R. Chiaramonte raffaella.chiaramonte@unimi.it