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The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia

Dept of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands;Dept. of Hematology, VU University Medical Center, Amsterdam, The Netherlands
Dept. of Biology, Technion-Israel Institute of Technology, Haifa, Israel
Dept of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands
Dept of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands;Dept. of Hematology, VU University Medical Center, Amsterdam, The Netherlands;Dept. of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
Dept. of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
Dept. of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands;Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands
Clinic of Pediatric Hematology/Oncology, University Medical Center Eppendorf, Hamburg, Germany
Dept of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands
Dept of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands;Dept. of Hematology, VU University Medical Center, Amsterdam, The Netherlands
Vol. 101 No. 7 (2016): July, 2016 https://doi.org/10.3324/haematol.2016.142794