We reviewed 64 pregnancies in 26 women with Diamond-Blackfan anemia (DBA) included in the French and German DBA registries. Complications were seen in 42 pregnancies (66%) and included abortion, pre-eclampsia, in utero fetal death, intrauterine growth retardation, retroplacental hematoma, pre-term delivery and fetal malformations. Of the 34 children (53%) born alive, 13 had DBA. No correlations were found between pregnancy outcome and features of either maternal or child DBA. Pregnancies in DBA-affected women are at high risk, especially for complications likely to be of vascular-placental origin. Careful monitoring with prevention of severe anemia and early introduction of aspirin is suggested.
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Vol. 91 No. 4 (2006): April, 2006 : Articles
Ferrata Storti Foundation, Pavia, Italy
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How to Cite
L Faivre, J Meerpohl, L Da Costa, I Marie, C Nouvel, A Gnekow, C Bender-Gotze, F Bauters, B Coiffier, PY Peaud, P Rispal, A Berrebi, C Berger, M Flesch, P Sagot, B Varet, C Niemeyer, G Tchernia, T Leblanc. High-risk pregnancies in Diamond-Blackfan anemia: a survey of 64 pregnancies from the French and German registries. Haematologica 2006;91(4):530-533; https://doi.org/10.3324/%x.