Abstract
A patient with a severe prothrombin deficiency and a hemorrhagic diathesis was found to have positive cross-reactive material in plasma and a homozygous F299V mutation (F7V in the A chain). This mutation reinforces the previous conclusion that the A chain affects the geometry of the catalytic triad. Marked prolongation of the Taipan venom and Russell venom clotting times also demonstrated a defective activation mechanism and a defective interaction with factor Xa.
Vol. 91 No. 3 (2006): March, 2006 : Case Reports
Published By
Ferrata Storti Foundation, Pavia, Italy
Statistics from Altmetric.com