TY - JOUR AU - D Francois, AU - C Chevreaud, AU - D Vignon, AU - P de Mazancourt, PY - 2006/03/01 Y2 - 2024/03/28 TI - Prothrombin Suresnes: a case of homozygous F299V mutation responsible for hypodysprothrombinemia JF - Haematologica JA - haematol VL - 91 IS - 3 SE - Case Reports DO - 10.3324/%x UR - https://haematologica.org/article/view/3908 SP - 431-432 AB - A patient with a severe prothrombin deficiency and a hemorrhagic diathesis was found to have positive cross-reactive material in plasma and a homozygous F299V mutation (F7V in the A chain). This mutation reinforces the previous conclusion that the A chain affects the geometry of the catalytic triad. Marked prolongation of the Taipan venom and Russell venom clotting times also demonstrated a defective activation mechanism and a defective interaction with factor Xa. ER -