AbstractLactadherin is a phosphatidylserine-binding glycoprotein secreted by macrophages. Less than 0.5% of normal circulating red cells showed any binding to lactadherin. However, the red cells from patients with sickle cell disease showed 2 to 10-fold increases in lactadherin binding. Further, lactadherin stimulated the phagocytosis of sickle red blood cells by macrophages suggesting a potential role in sickle red cell clearance.
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Vol. 90 No. 9 (2005): September, 2005 : Comparative Studies
Ferrata Storti Foundation, Pavia, Italy
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