Infections constitute a principal cause of morbidity and mortality in sickle cell anemia (SCA). Here we present evidence to suggest that a polymorphism (G-463A MPO) in the gene encoding the myeloperoxidase (MPO) enzyme, important for the host defense system, may significantly increase susceptibility to infection in SCA.
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Vol. 90 No. 7 (2005): July, 2005 : Letters to the Editor
RN Costa, N Conran, DM Albuquerque, PH Soares, ST Saad, FF Costa. Association of the G-463A myeloperoxidase polymorphism with infection in sickle cell anemia. Haematologica 2005; 90(7):977-979; https://doi.org/10.3324/%x.
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