We screened 100 children with acute lymphoblastic leukemia (ALL) to assess the incidence of single amino acid change A91V in perforin. Heterozygous A91V was found in 12/100 patients and 5/127 controls (OR, 3.4; 95%CI: 1.15-9.95; p=0.014). A91V is a novel and frequent predisposing factor for childhood ALL.
Figures & Tables
Vol. 90 No. 5 (2005): May, 2005 : Letters to the Editor
Ferrata Storti Foundation, Pavia, Italy
Statistics from Altmetric.com
How to Cite
A Santoro, S Cannella, A Trizzino, L Lo Nigro, G Corsello, M Arico. A single amino acid change A91V in perforin: a novel, frequent predisposing factor to childhood acute lymphoblastic leukemia?. Haematologica 2005;90(5):697-698; https://doi.org/10.3324/%x.