Abstract
We screened 100 children with acute lymphoblastic leukemia (ALL) to assess the incidence of single amino acid change A91V in perforin. Heterozygous A91V was found in 12/100 patients and 5/127 controls (OR, 3.4; 95%CI: 1.15-9.95; p=0.014). A91V is a novel and frequent predisposing factor for childhood ALL.
Vol. 90 No. 5 (2005): May, 2005 : Letters to the Editor
Published By
Ferrata Storti Foundation, Pavia, Italy
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