A total of 173 samples obtained from adult patients with de novo acute myeloid leukemia (AML) were assayed for exon 3 PTPN11 mutations by single strand conformation polymorphism (SSCP) analysis and direct sequencing. Only three monocytic leukemias had point mutations (1.73%).
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Vol. 90 No. 3 (2005): March, 2005 : Letters to the Editor
J Nomdedeu, MT Carricondo, A Lasa, G Perea, A Aventin, J Sierra. Low frequency of exon 3 PTPN11 mutations in adult de novo acute myeloid leukemia. Analysis of a consecutive series of 173 patients. Haematologica 2005; 90(3):412-413; https://doi.org/10.3324/%x.
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