Aberrant expression of platelet-derived growth factor (PDGF) and PDGF receptor-alpha is associated with advanced bone marrow fibrosis in idiopathic myelofibrosis

Abstract

The expression of members of the platelet-derived growth factor (PDGF) system in bone marrow cells derived from Idiopathic myelofibrosis (IMF) has been investigated by real-time RT-PCR. Increased expression of PDGFs and the corresponding PDGF receptor a could be demonstrated to be a feature of advanced fibrosis in IMF that is not demonstrable in the prefibrotic phase of the disease.