We describe the case of a 39-year-old woman who suffered two iliofemoral venous thromboses, a cerebral ischemic infarct and recurrent fetal loss. Initial studies showed high levels of antiphospholipid antibodies (APAs) and a moderate thrombocytopenia. After her second miscarriage, laboratory diagnosis revealed that the woman was heterozygous for the factor V Leiden mutation and had a functional protein S deficiency as well as anti-protein S and anti-beta 2-glycoprotein I antibodies. The impairment of the protein C pathway at various points could well explain the recurrent thromboses in the patient and supports the role of a disturbed protein C system in the pathophysiology of thrombosis in patients with APAs.
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Vol. 84 No. 1 (1999): January, 1999 : Case Reports
Ferrata Storti Foundation, Pavia, Italy
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How to Cite
F Espana, P Villa, Y Mira, S Grancha, M Royo, A Estelles, A Vaya, J Aznar. Factor V Leiden and antibodies against phospholipids and protein S in a young woman with recurrent thromboses and abortion. Haematologica 1999;84(1):80-84; https://doi.org/10.3324/%x.