We studied a patient who developed pure red cell aplasia (PRCA) following peripheral stem cell transplantation for non-Hodgkin lymphoma. Serum erythropoietin was appropriate for the degree of anemia. Corticosteroid treatment was ineffective. Four months after transplantation rHuEpo was administered subcutaneously at a dose of 150 U/Kg per day, five days a week for 8 weeks. Treatment induced an erythropoietic response and corrected anemia. Response was maintained following discontinuation of rHuEpo. This study and previous reports indicate that high doses of rHuEpo given over a short time can resolve PRCA following autologous or allogeneic stem cell transplantation.
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Vol. 79 No. 5 (1994): September, 1994 : Case Reports
Ferrata Storti Foundation, Pavia, Italy
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How to Cite
M Martelli, L Ponchio, Y Beguin, G Meloni, F Mandelli, M Cazzola. Pure red cell aplasia following peripheral stem cell transplantation: complete response to a short course of high-dose recombinant human erythropoietin. Haematologica 1994;79(5):456-459; https://doi.org/10.3324/%x.