AbstractAbnormal adhesion of red blood cells to the endothelium and the production of cytokines and vasoactive substances, such as endothelin-1 contribute to the pathogenesis of microvascular occlusion in sickle cell disease (SCD), even during the steady state. Endothelin-3 (ET-3) is a vasoconstrictive agent, which has not yet been studied in SCD.
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Vol. 89 No. 3 (2004): March, 2004 : Letters to the Editor
Ferrata Storti Foundation, Pavia, Italy
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