Case Reports

Single-cell dissection of plasma cell clonal evolution to smoldering multiple myeloma after CD19 CAR-T cell therapy in B-cell acute lymphoblastic leukemia

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMSandPUMC), Tianjin, 301600
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS-PUMC), Tianjin, 301600
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS-PUMC), Tianjin, 301600
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS-PUMC), Tianjin, 301600
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS-PUMC), Tianjin, 301600
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS-PUMC), Tianjin, 301600
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS-PUMC), Tianjin, 301600
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS-PUMC), Tianjin, 301600
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS-PUMC), Tianjin, 301600
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS-PUMC), Tianjin, 301600
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS-PUMC), Tianjin, 301600
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS-PUMC), Tianjin, 301600
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS-PUMC), Tianjin, 301600
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS-PUMC), Tianjin, 301600
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS-PUMC), Tianjin, 301600
Haematologica Early view Feb 12, 2026 https://doi.org/10.3324/haematol.2025.300240