Review Articles

Targeting the tumor microenvironment in chronic lymphocytic leukemia (351 Online Views)

Rebecka Svanberg, Sine Janum, Piers E.M. Patten, Alan G. Ramsay, Carsten U. Niemann



The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance (264 Online Views)

Yasith Mathangasinghe, Bruno Fauvet, Stephen M. Jane, Pierre Goloubinoff, Nadinath B. Nillegoda



European Myeloma Network perspective on CAR T-Cell therapies for multiple myeloma (882 Online Views)

Benedetto Bruno, Ralph Wäsch, Monika Engelhardt, Francesca Gay, Luisa Giaccone, Mattia D’Agostino, Luis-Gerardo Rodríguez-Lobato, Sophia Danhof, Nico Gagelmann, Nicolaus Kröger, Rakesh Popat, Niels W.C.J. van de Donk, Evangelos Terpos, Meletios A. Dimopoulos, Pieter Sonneveld, Hermann Einsele, Mario Boccadoro



T-cell dysfunction in chronic lymphocytic leukemia from an epigenetic perspective (777 Online Views)

Fleur S. Peters, Jonathan C. Strefford, Eric Eldering, Arnon P. Kater


Chronic organ injuries in children with sickle cell disease (251 Online Views)

Slimane Allali, Melissa Taylor, Joséphine Brice, Mariane de Montalembert



Latest culture techniques: cracking the secrets of bone marrow to mass-produce erythrocytes and platelets ex vivo (821 Online Views)

Christian A. Di Buduo, Alicia Aguilar, Paolo M. Soprano, Alberto Bocconi, Carolina P. Miguel, Giovanna Mantica, Alessandra Balduini













Clonal hematopoietic mutations linked to platelet traits and the risk of thrombosis or bleeding (1369 Online Views)

Alicia Veninga, Ilaria De Simone, Johan W.M. Heemskerk, Hugo ten Cate, Paola E.J. van der Meijden





Multiple myeloma with central nervous system relapse (2802 Online Views)

Philip A. Egan, Patrick T Elder, W. Ian Deighan, Sheila J.M. O’Connor, H. Denis Alexander


Geriatric assessment in older patients with a hematologic malignancy: a systematic review (1402 Online Views)

Ellen R.M. Scheepers, Ariel M. Vondeling, Noortje Thielen, René van der Griend, Reinhard Stauder, Marije E. Hamaker






How I curate: applying American Society of Hematology-Clinical Genome Resource Myeloid Malignancy Variant Curation Expert Panel rules for RUNX1 variant curation for germline predisposition to myeloid malignancies (889 Online Views)

David Wu, Xi Luo, Simone Feurstein, Chimene Kesserwan, Shruthi Mohan, Daniel E. Pineda-Alvarez, Lucy A. Godley, on behalf of the collaborative group of the American Society of Hematology - Clinical Genome Resource Myeloid Malignancy Variant Curation Expert Panel


Glanzmann thrombasthenia: genetic basis and clinical correlates (3413 Online Views)

Juliana Perez Botero, Kristy Lee, Brian R Branchford, Paul F Bray, Kathleen Freson, Michele P. Lambert, Minjie Luo, Shruthi Mohan, Justyne E. Ross, Wolfgang Bergmeier, Jorge Di Paola


The variable manifestations of disease in pyruvate kinase deficiency and their management (3312 Online Views)

Hanny Al-Samkari, Eduard J. van Beers, Kevin H.M. Kuo, Wilma Barcellini, Paola Bianchi, Andreas Glenthøj, María del Mar Mañú Pereira, Richard van Wijk, Bertil Glader, Rachael F. Grace


An international registry of patients with plasminogen deficiency (HISTORY) (612 Online Views)

Amy D. Shapiro, Marzia Menegatti, Roberta Palla, Marco Boscarino, Christopher Roberson, Paolo Lanzi, Joel Bowen, Charles Nakar, Isaac A. Janson, Flora Peyvandi


Seronegative antiphospholipid syndrome: refining the value of “non-criteria” antibodies for diagnosis and clinical management (3858 Online Views)

Pasquale Pignatelli, Evaristo Ettorre, Danilo Menichelli, Arianna Pani, Francesco Violi, Daniele Pastori


Innate immune cells, major protagonists of sickle cell disease pathophysiology (1087 Online Views)

Slimane Allali, Thiago Trovati Maciel, Olivier Hermine, Mariane de Montalembert


Fibrin(ogen) in human disease: both friend and foe (9114 Online Views)

Rui Vilar, Richard J. Fish, Alessandro Casini, Marguerite Neerman-Arbez




MYD88 in the driver’s seat of B-cell lymphomagenesis: from molecular mechanisms to clinical implications (2277 Online Views)

Ruben A.L. de Groen, Anne M.R. Schrader, Marie José Kersten, Steven T. Pals, Joost S.P. Vermaat






Updates on the hematologic tumor microenvironment and its therapeutic targeting (1119 Online Views)

Dorian Forte, Daniela S. Krause, Michael Andreeff, Dominique Bonnet, Simón Méndez-Ferrer








Thrombopoietin receptor agonists: ten years later (5301 Online Views)

Waleed Ghanima, Nichola Cooper, Francesco Rodeghiero, Bertrand Godeau, James B. Bussel




CRISPR to fix bad blood: a new tool in basic and clinical hematology (2887 Online Views)

Elisa González-Romero, Cristina Martínez-Valiente, Cristian García-Ruiz, Rafael P. Vázquez-Manrique, José Cervera, Alejandra Sanjuan-Pla



State-of-the-art review: allogeneic stem cell transplantation for myelofibrosis in 2019 (3208 Online Views)

Donal P. McLornan, Ibrahim Yakoub-Agha, Marie Robin, Yves Chalandon, Claire N. Harrison, Nicolaus Kroger



IgG4-related disease: what a hematologist needs to know (27714 Online Views)

Luke Y.C. Chen, Andre Mattman, Michael A. Seidman, Mollie N. Carruthers


CD30-positive primary cutaneous lymphoproliferative disorders: molecular alterations and targeted therapies (1630 Online Views)

Lucia Prieto-Torres, Socorro M. Rodriguez-Pinilla, Arantza Onaindia, Mariano Ara, Luis Requena, Miguel Á. Piris






TP53 aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics (4216 Online Views)

Elias Campo, Florence Cymbalista, Paolo Ghia, Ulrich Jäger, Sarka Pospisilova, Richard Rosenquist, Anna Schuh, Stephan Stilgenbauer


Preclinical human models and emerging therapeutics for advanced systemic mastocytosis (533 Online Views)

Michel Arock, Ghaith Wedeh, Gregor Hoermann, Siham Bibi, Cem Akin, Barbara Peter, Karoline V. Gleixner, Karin Hartmann, Joseph H. Butterfield, Dean D. Metcalfe, Peter Valent



Normal and pathological erythropoiesis in adults: from gene regulation to targeted treatment concepts (3259 Online Views)

Peter Valent, Guntram Büsche, Igor Theurl, Iris Z. Uras, Ulrich Germing, Reinhard Stauder, Karl Sotlar, Wolfgang Füreder, Peter Bettelheim, Michael Pfeilstöcker, Rainer Oberbauer, Wolfgang R. Sperr, Klaus Geissler, Jürg Schwaller, Richard Moriggl, Marie C. Béné, Ulrich Jäger, Hans-Peter Horny, Olivier Hermine


Cardiovascular adverse events in modern myeloma therapy – Incidence and risks. A review from the European Myeloma Network (EMN) and Italian Society of Arterial Hypertension (SIIA) (753 Online Views)

Sara Bringhen, Alberto Milan, Claudio Ferri, Ralph Wäsch, Francesca Gay, Alessandra Larocca, Marco Salvini, Evangelos Terpos, Hartmut Goldschmidt, Michele Cavo, Maria Teresa Petrucci, Heinz Ludwig, Holger W. Auner, Jo Caers, Martin Gramatzki, Mario Boccadoro, Hermann Einsele, Pieter Sonneveld, Monika Engelhardt




Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers (1047 Online Views)

Johana Hrdinová, Silvia D’Angelo, Nuno A. G. Graça, Bogac Ercig, Karen Vanhoorelbeke, Agnès Veyradier, Jan Voorberg, Paul Coppo





From transplant to novel cellular therapies in multiple myeloma: European Myeloma Network guidelines and future perspectives (1181 Online Views)

Francesca Gay, Monika Engelhardt, Evangelos Terpos, Ralph Wäsch, Luisa Giaccone, Holger W. Auner, Jo Caers, Martin Gramatzki, Niels van de Donk, Stefania Oliva, Elena Zamagni, Laurent Garderet, Christian Straka, Roman Hajek, Heinz Ludwig, Herman Einsele, Meletios Dimopoulos, Mario Boccadoro, Nicolaus Kröger, Michele Cavo, Hartmut Goldschmidt, Benedetto Bruno, Pieter Sonneveld


The prothrombotic state in paroxysmal nocturnal hemoglobinuria: a multifaceted source (960 Online Views)

Barnaby Peacock-Young, Fraser L. Macrae, Darren J. Newton, Anita Hill, Robert A S Ariëns








Is immunotherapy here to stay in multiple myeloma? (507 Online Views)

Paula Rodríguez-Otero, Bruno Paiva, Monika Engelhardt, Felipe Prósper, Jesús F. San Miguel


Propagation of thrombosis by neutrophils and extracellular nucleosome networks (579 Online Views)

Susanne Pfeiler, Konstantin Stark, Steffen Massberg, Bernd Engelmann



Anti-thymocyte globulin as graft-versus-host disease prevention in the setting of allogeneic peripheral blood stem cell transplantation: a review from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (598 Online Views)

Frédéric Baron, Mohamad Mohty, Didier Blaise, Gérard Socié, Myriam Labopin, Jordi Esteve, Fabio Ciceri, Sebastian Giebel, Norbert Claude Gorin, Bipin N Savani, Christoph Schmid, Arnon Nagler



The emerging role of immune checkpoint inhibition in malignant lymphoma (524 Online Views)

Ida Hude, Stephanie Sasse, Andreas Engert, Paul J. Bröckelmann



The myeloma stem cell concept, revisited: from phenomenology to operational terms (1033 Online Views)

Hans Erik Johnsen, Martin Bøgsted, Alexander Schmitz, Julie Støve Bødker, Tarec Christoffer El-Galaly, Preben Johansen, Peter Valent, Niklas Zojer, Els Van Valckenborgh, Karin Vanderkerken, Mark van Duin, Pieter Sonneveld, Martin Perez-Andres, Alberto Orfao, Karen Dybkær


‘Trained immunity’: consequences for lymphoid malignancies (471 Online Views)

Wendy B.C. Stevens, Mihai G. Netea, Arnon P. Kater, Walter J.F.M. van der Velden


New insights on hereditary erythrocyte membrane defects (1971 Online Views)

Immacolata Andolfo, Roberta Russo, Antonella Gambale, Achille Iolascon


Osteonecrosis in children with acute lymphoblastic leukemia (758 Online Views)

Marina Kunstreich, Sebastian Kummer, Hans-Juergen Laws, Arndt Borkhardt, Michaela Kuhlen


Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice (1181 Online Views)

Celalettin Ustun, Michel Arock, Hanneke C. Kluin-Nelemans, Andreas Reiter, Wolfgang R. Sperr, Tracy George, Hans-Peter Horny, Karin Hartmann, Karl Sotlar, Gandhi Damaj, Olivier Hermine, Srdan Verstovsek, Dean D. Metcalfe, Jason Gotlib, Cem Akin, Peter Valent



Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond (523 Online Views)

Richard Rosenquist, Andreas Rosenwald, Ming-Qing Du, Gianluca Gaidano, Patricia Groenen, Andrew Wotherspoon, Paolo Ghia, Philippe Gaulard, Elias Campo, Kostas Stamatopoulos






Bone marrow fibrosis in myelofibrosis: pathogenesis, prognosis and targeted strategies (2420 Online Views)

Abdallah Abou Zahr, Mohamed E. Salama, Nicole Carreau, Douglas Tremblay, Srdan Verstovsek, Ruben Mesa, Ronald Hoffman, John Mascarenhas





Role of the tumor microenvironment in mature B-cell lymphoid malignancies (732 Online Views)

Nathan H. Fowler, Chan Yoon Cheah, Randy D. Gascoyne, John Gribben, Sattva S. Neelapu, Paolo Ghia, Catherine Bollard, Stephen Ansell, Michael Curran, Wyndham H. Wilson, Susan O’Brien, Cliona Grant, Richard Little, Thorsten Zenz, Loretta J. Nastoupil, Kieron Dunleavy


Chronic myeloid leukemia: reminiscences and dreams (2337 Online Views)

Tariq I. Mughal, Jerald P. Radich, Michael W. Deininger, Jane F. Apperley, Timothy P. Hughes, Christine J. Harrison, Carlo Gambacorti-Passerini, Giuseppe Saglio, Jorge Cortes, George Q. Daley






Risk factors for relapse after allogeneic transplantation in acute myeloid leukemia (448 Online Views)

Gert J. Ossenkoppele, Jeroen J.W.M. Janssen, Arjan A. van de Loosdrecht


Humanized hemato-lymphoid system mice (1125 Online Views)

Alexandre P.A. Theocharides, Anthony Rongvaux, Kristin Fritsch, Richard A. Flavell, Markus G. Manz






Environmental determinants of severity in sickle cell disease (2112 Online Views)

Sanjay Tewari, Valentine Brousse, Frédéric B. Piel, Stephan Menzel, David C. Rees







Epigenetics in the hematologic malignancies (406 Online Views)

Chun Yew Fong, Jessica Morison, Mark A. Dawson






Survival analysis in hematologic malignancies: recommendations for clinicians (689 Online Views)

Julio Delgado, Arturo Pereira, Neus Villamor, Armando López-Guillermo, Ciril Rozman


Early lymphoid lesions: conceptual, diagnostic and clinical challenges (561 Online Views)

Karthik A. Ganapathi, Stefania Pittaluga, Oreofe O. Odejide, Arnold S. Freedman, Elaine S. Jaffe



The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy (632 Online Views)

Graham Packham, Serge Krysov, Alex Allen, Natalia Savelyeva, Andrew J. Steele, Francesco Forconi, Freda K. Stevenson




Heme and erythropoieis: more than a structural role (714 Online Views)

Deborah Chiabrando, Sonia Mercurio, Emanuela Tolosano


Nature and importance of follicular lymphoma precursors (703 Online Views)

Emilie Mamessier, Florence Broussais-Guillaumot, Bruno Chetaille, Reda Bouabdallah, Luc Xerri, Elaine S. Jaffe, Bertrand Nadel


Why methylation is not a marker predictive of response to hypomethylating agents (596 Online Views)

Maria Teresa Voso, Valeria Santini, Emiliano Fabiani, Luana Fianchi, Marianna Criscuolo, Giulia Falconi, Francesco Guidi, Stefan Hohaus, Giuseppe Leone


Primary thrombocytosis in children (1583 Online Views)

Nicole Kucine, Katherine M. Chastain, Michelle B. Mahler, James B. Bussel



Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy (756 Online Views)

Siham Bibi, Melis Dilara Arslanhan, Florent Langenfeld, Sylvie Jeanningros, Sabine Cerny-Reiterer, Emir Hadzijusufovic, Luba Tchertanov, Richard Moriggl, Peter Valent, Michel Arock


Management and treatment of osteonecrosis in children and adolescents with acute lymphoblastic leukemia (405 Online Views)

Mariël L. te Winkel, Rob Pieters, Ernst-Jan D. Wind, J.H.J.M. (Gert) Bessems, Marry M. van den Heuvel-Eibrink


Measurement of adherence to BCR-ABL inhibitor therapy in chronic myeloid leukemia: current situation and future challenges (326 Online Views)

Lucien Noens, Marja Hensen, Izabela Kucmin-Bemelmans, Christina Lofgren, Isabelle Gilloteau, Bernard Vrijens


Update on treatment of light chain amyloidosis (1698 Online Views)

Shameem Mahmood, Giovanni Palladini, Vaishali Sanchorawala, Ashutosh Wechalekar


B-cell lymphoma mutations: improving diagnostics and enabling targeted therapies (582 Online Views)

José P. Vaqué, Nerea Martínez, Ana Batlle-López, Cristina Pérez, Santiago Montes-Moreno, Margarita Sánchez-Beato, Miguel A. Piris


Targeting the phosphoinositide 3-kinase pathway in hematologic malignancies (577 Online Views)

Elias Jabbour, Oliver G. Ottmann, Michael Deininger, Andreas Hochhaus



Advances in myelofibrosis: a clinical case approach (589 Online Views)

John O. Mascarenhas, Attilio Orazi, Kapil N. Bhalla, Richard E. Champlin, Claire Harrison, Ronald Hoffman


Autophagy in blood cancers: biological role and therapeutic implications (397 Online Views)

Alessio Nencioni, Michele Cea, Fabrizio Montecucco, Valter D. Longo, Franco Patrone, Angelo M. Carella, Tessa L. Holyoake, G. Vignir Helgason


Management recommendations for chronic myelomonocytic leukemia: consensus statements from the SIE, SIES, GITMO groups (359 Online Views)

Francesco Onida, Giovanni Barosi, Giuseppe Leone, Luca Malcovati, Enrica Morra, Valeria Santini, Giorgina Specchia, Sante Tura



Classical Hodgkin’s lymphoma: the Lymphoma Study Association guidelines for relapsed and refractory adult patients eligible for transplant (357 Online Views)

Eric Van Den Neste, Olivier Casasnovas, Marc André, Mohamed Touati, Delphine Senecal, Véronique Edeline, Aspasia Stamatoullas, Luc Fornecker, Bénédicte Deau, Thomas Gastinne, Oumédaly Reman, Isabelle Gaillard, Cécile Borel, Pauline Brice, Christophe Fermé



Indications for hematopoietic stem cell transplantation in patients with follicular lymphoma: a consensus project of the EBMT-Lymphoma Working Party (306 Online Views)

Silvia Montoto, Paolo Corradini, Martin Dreyling, Michele Ghielmini, Eva Kimby, Armando López-Guillermo, Stephen Mackinnon, Robert E. Marcus, Gilles Salles, Harry C Schouten, Anna Sureda, Peter Dreger


Non-transfusion-dependent thalassemias (1308 Online Views)

Khaled M. Musallam, Stefano Rivella, Elliott Vichinsky, Eliezer A. Rachmilewitz


Iron refractory iron deficiency anemia (948 Online Views)

Luigia De Falco, Mayka Sanchez, Laura Silvestri, Caroline Kannengiesser, Martina U. Muckenthaler, Achille Iolascon, Laurent Gouya, Clara Camaschella, Carole Beaumont



Clinical implications of the molecular genetics of chronic lymphocytic leukemia (532 Online Views)

Robin Foà, Ilaria Del Giudice, Anna Guarini, Davide Rossi, Gianluca Gaidano


Diagnosis and treatment of mucormycosis in patients with hematological malignancies: guidelines from the 3rd European Conference on Infections in Leukemia (ECIL 3) (1226 Online Views)

Anna Skiada, Fanny Lanternier, Andreas H. Groll, Livio Pagano, Stephan Zimmerli, Raoul Herbrecht, Olivier Lortholary, George L. Petrikkos





Infections in myelodysplastic syndromes (649 Online Views)

Andréa Toma, Pierre Fenaux, François Dreyfus, Catherine Cordonnier


Molecular pathogenesis of Waldenström’s macroglobulinemia (418 Online Views)

Esteban Braggio, Casey Philipsborn, Anne Novak, Lucy Hodge, Stephen Ansell, Rafael Fonseca




Acute myeloid leukemia developing in patients with autoimmune diseases (863 Online Views)

Safaa M. Ramadan, Tamer M Fouad, Valentina Summa, Syed KH Hasan, Francesco Lo-Coco


Thrombolytic therapy for central venous catheter occlusion (804 Online Views)

Jacquelyn L. Baskin, Ulrike Reiss, Judith A. Wilimas, Monika L. Metzger, Raul C. Ribeiro, Ching-Hon Pui, Scott C. Howard





An overview of the progress on double umbilical cord blood transplantation (204 Online Views)

Anastasia Sideri, Nikolaos Neokleous, Philippe Brunet De La Grange, Bernadette Guerton, Marie-Caroline Le Bousse Kerdilles, Georges Uzan, Corina Peste-Tsilimidos, Eliane Gluckman




Chronic lymphocytic leukemia and autoimmunity: a systematic review (1240 Online Views)

Kate Hodgson, Gerardo Ferrer, Emili Montserrat, Carol Moreno


The Ph-positive and Ph-negative myeloproliferative neoplasms: some topical pre-clinical and clinical issues (329 Online Views)

Richard A. Van Etten, Steffen Koschmieder, Francois Delhommeau, Danilo Perrotti, Tessa Holyoake, Animesh Pardanani, Ruben Mesa, Tony Green, Amr R. Ibrahim, Tariq Mughal, Robert Peter Gale, John Goldman


The interplay between Epstein-Barr virus and the immune system: a rationale for adoptive cell therapy of EBV-related disorders (678 Online Views)

Anna Merlo, Riccardo Turrini, Riccardo Dolcetti, Debora Martorelli, Elena Muraro, Patrizia Comoli, Antonio Rosato



PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers (699 Online Views)

Laurent Brault, Christelle Gasser, Franz Bracher, Kilian Huber, Stefan Knapp, Jürg Schwaller


Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia (996 Online Views)

Sophie Park, Nicolas Chapuis, Jérôme Tamburini, Valérie Bardet, Pascale Cornillet-Lefebvre, Lise Willems, Alexa Green, Patrick Mayeux, Catherine Lacombe, Didier Bouscary



Lymphoma stem cells: enough evidence to support their existence? (579 Online Views)

Jose A. Martinez-Climent, Lorena Fontan, Randy D. Gascoyne, Reiner Siebert, Felipe Prosper


Anti-CD20 monoclonal antibodies: historical and future perspectives (643 Online Views)

Sean H. Lim, Stephen A. Beers, Ruth R. French, Peter W.M. Johnson, Martin J. Glennie, Mark S. Cragg


Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies (263 Online Views)

Sigurdur Y. Kristinsson, Lynn R. Goldin, Magnus Björkholm, Jill Koshiol, Ingemar Turesson, Ola Landgren




Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis (651 Online Views)

Andrew J. Ramsay, John D. Hooper, Alicia R. Folgueras, Gloria Velasco, Carlos López-Otín


Platelet receptors and signaling in the dynamics of thrombus formation (1660 Online Views)

José Rivera, María Luisa Lozano, Leyre Navarro-Núñez, Vicente Vicente



Mesenchymal stem cells: the fibroblasts’ new clothes? (917 Online Views)

Muzlifah A. Haniffa, Matthew P. Collin, Christopher D. Buckley, Francesco Dazzi