Tibullo, D., Longhitano, L., Ferrigno, J., La Spina, E., Conti, G., Bellia, F., Amorini, A., Giallongo, S., Duminuco, A., Palumbo, G., Dulcamare, I., Conticello, C., Cambria, D., Calvo, D., Zuppelli, T., Cantafio, M. G., Volti, G. L., Amodio, N., -, D. R., Romano, A. and Giallongo, C. (2026) “P098 | Glutamine-dependent anaplerotic rewiring with pyruvate carboxylase down-tuning underlies proteasome inhibitors resistance in multiple myeloma: D. Tibullo1, L. Longhitano1, J Ferrigno1, E. La Spina1, G.N. Conti1, F. Bellia1, A.M. Amorini1, S. Giallongo2, A. Duminuco3, G.A. Palumbo3, I. Dulcamare4, C. Conticello5, D. Cambria4, D. Calvo1, T. Zuppelli1, Me Gallo Cantafio5, G. Li Volti1, N. Amodio5, Di Raimondo4, A. Romano4, C. Giallongo1 | 1Department of Biomedical and Biotechnological Sciences, University of Catania; 2Faculty of Medicine and Surgery, University of Enna “Kore”; 3Department of Medical and Surgical Sciences and Advanced Technologies ‘G. F. Ingrassia’, University of Catania; 4Department of General Surgery and Medical-Surgical Specialties- University of Catania, Division of Haematology; 5Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Italy.”, Haematologica. Pavia, Italy, 111(s1). doi: 10.3324/haematol.2026.s1.155.