Francesca Schieppati, Piera Balzarini, Simona Fisogni, Alessandro Re, Chiara Pagani, Nicola Bianchetti, Lorenzo Micheli, Angela Passi, Samantha Ferrari, Adriana Maifredi, Chiara Bottelli, Rossella Leopaldo, Vilma Pellegrini, Fabio Facchetti, Giuseppe Rossi, Alessandra Tucci. An increase in MYC copy number has a progressive negative prognostic impact in patients with diffuse large B-cell and high-grade lymphoma, who may benefit from intensified treatment regimens. Haematologica 2020;105(5):1369-1378; https://doi.org/10.3324/haematol.2019.223891.