Pegoraro F, Trambusti I, Sieni E. Neurodegenerative Langerhans cell histiocytosis: building the evidence for prospective monitoring and early treatment. Response to Comment on: “Neurodegenerative Langerhans cell histiocytosis: longterm follow-up of 63 patients from the Italian Registry”. Haematologica; https://doi.org/10.3324/haematol.2026.301539 [Early view].