Tibullo D, Longhitano L, Ferrigno J, La Spina E, Conti G, Bellia F, Amorini A, Giallongo S, Duminuco A, Palumbo G, Dulcamare I, Conticello C, Cambria D, Calvo D, Zuppelli T, Cantafio MG, Volti GL, Amodio N, - DR, Romano A, Giallongo C. P098 | Glutamine-dependent anaplerotic rewiring with pyruvate carboxylase down-tuning underlies proteasome inhibitors resistance in multiple myeloma: D. Tibullo1, L. Longhitano1, J Ferrigno1, E. La Spina1, G.N. Conti1, F. Bellia1, A.M. Amorini1, S. Giallongo2, A. Duminuco3, G.A. Palumbo3, I. Dulcamare4, C. Conticello5, D. Cambria4, D. Calvo1, T. Zuppelli1, Me Gallo Cantafio5, G. Li Volti1, N. Amodio5, Di Raimondo4, A. Romano4, C. Giallongo1 | 1Department of Biomedical and Biotechnological Sciences, University of Catania; 2Faculty of Medicine and Surgery, University of Enna “Kore”; 3Department of Medical and Surgical Sciences and Advanced Technologies “G. F. Ingrassia”, University of Catania; 4Department of General Surgery and Medical-Surgical Specialties- University of Catania, Division of Haematology; 5Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Italy. Haematologica 2026; 111(s1); https://doi.org/10.3324/haematol.2026.s1.155.