Corsale A, Speciale M, Aquilina C, Gigliotta E, Rizzuto A, Biondo M, Tofacchi E, Romano A, Di Simone M, Gallo A, Caccamo N, Dieli F, Meraviglia S, Siragusa S, Botta C. CO21 | Integrated multiomic immune profiling defines the biological basis of minimal residual disease persistence in multiple myeloma: A.M. Corsale1, M. Speciale2, C. Aquilina1, E. Gigliotta1, A. Rizzuto1, M. Biondo3, E. Tofacchi1, A. Romano1, M. Di Simone1, A. Gallo4, N. Caccamo5, F. Dieli5, S. Meraviglia5, S. Siragusa1, C. Botta1 | 1Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo; 2Department of Surgical, Oncological and Stomatological Disciplines, DICHIRONS, University of Palermo; 3Department of General Surgery and Medical-Surgical Specialties, Hematology Section, University of Catania; 4Department of Research, IRCCS-ISMETT, Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione; 5Department of Biomedicine, Neuroscience and Advanced Diagnosis, Bi. N. D. , University of Palermo. Haematologica 2026; 111(s1); https://doi.org/10.3324/haematol.2026.s1.34.