TY - JOUR AU - Satoko Morishima, AU - Koichi Kashiwase, AU - Keitaro Matsuo, AU - Fumihiro Azuma, AU - Toshio Yabe, AU - Aiko Sato-Otsubo, AU - Seishi Ogawa, AU - Takashi Shiina, AU - Masahiro Satake, AU - Hiroh Saji, AU - Shunichi Kato, AU - Yoshihisa Kodera, AU - Takehiko Sasazuki, AU - Yasuo Morishima, PY - 2016/03/31 Y2 - 2024/03/28 TI - High-risk HLA alleles for severe acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation JF - Haematologica JA - haematol VL - 101 IS - 4 SE - Articles DO - 10.3324/haematol.2015.136903 UR - https://haematologica.org/article/view/7685 SP - 491-498 AB - HLA molecules play an important role for immunoreactivity in allogeneic hematopoietic stem cell transplantation. To elucidate the effect of specific HLA alleles on acute graft-versus-host disease, we conducted a retrospective analysis using 6967 Japanese patients transplanted with T-cell-replete marrow from an unrelated donor. Using unbiased searches of patient and donor HLA alleles, patient and/or donor HLA-B*51:01 (patient: HR, 1.37, P