TY - JOUR AU - Chi Keung Cheng, AU - Natalie P. H. Chan, AU - Thomas S. K. Wan, AU - Lai Ying Lam, AU - Coty H. Y. Cheung, AU - Terry H. Y. Wong, AU - Rosalina K. L. Ip, AU - Raymond S. M. Wong, AU - Margaret H. L. Ng, PY - 2016/03/31 Y2 - 2024/03/28 TI - Helicase-like transcription factor is a RUNX1 target whose downregulation promotes genomic instability and correlates with complex cytogenetic features in acute myeloid leukemia JF - Haematologica JA - haematol VL - 101 IS - 4 SE - Articles DO - 10.3324/haematol.2015.137125 UR - https://haematologica.org/article/view/7680 SP - 448-457 AB - Helicase-like transcription factor is a SWI/SNF chromatin remodeling factor involved in various biological processes. However, little is known about its role in hematopoiesis. In this study, we measured helicase-like transcription factor mRNA expression in the bone marrow of 204 adult patients with de novo acute myeloid leukemia. Patients were dichotomized into low and high expression groups at the median level for clinicopathological correlations. Helicase-like transcription factor levels were dramatically reduced in the low expression patient group compared to those in the normal controls (n=40) (P