TY - JOUR AU - Robert N. Lown, AU - Sameer Tulpule, AU - Nigel H. Russell, AU - Charles F. Craddock, AU - Rochelle Roest, AU - J. Alejandro Madrigal, AU - Bronwen E. Shaw, PY - 2013/12/09 Y2 - 2024/03/28 TI - Subsequent donation requests among 2472 unrelated hematopoietic progenitor cell donors are associated with bone marrow harvest JF - Haematologica JA - haematol VL - 98 IS - 12 SE - Articles DO - 10.3324/haematol.2013.088971 UR - https://haematologica.org/article/view/6872 SP - 1956-1963 AB - Approximately 1 in 20 unrelated donors are asked to make a second donation of hematopoietic progenitor cells, the majority for the same patient. Anthony Nolan undertook a study of subsequent hematopoietic progenitor cell donations made by its donors from 2005 to 2011, with the aims of predicting those donors more likely to be called for a second donation, assessing rates of serious adverse reactions and examining harvest yields. This was not a study of factors predictive of second allografts. During the study period 2591 donations were made, of which 120 (4.6%) were subsequent donations. The median time between donations was 179 days (range, 21–4016). Indications for a second allogeneic transplant included primary graft failure (11.7%), secondary graft failure (53.2%), relapse (30.6%) and others (1.8%). On multivariate analysis, bone marrow harvest at first donation was associated with subsequent donation requests (odds ratio 2.00, P=0.001). The rate of serious adverse reactions in donors making a subsequent donation appeared greater than the rate in those making a first donation (relative risk=3.29, P=0.005). Harvest yields per kilogram recipient body weight were equivalent between donations, although females appeared to have a lower yield at the subsequent donation. Knowledge of these factors will help unrelated donor registries to counsel their donors. ER -