TY - JOUR AU - Stefanie A. Hartsink-Segers, AU - Carla Exalto, AU - Matthew Allen, AU - Daniel Williamson, AU - Steven C. Clifford, AU - Martin Horstmann, AU - Huib N. Caron, AU - Rob Pieters, AU - Monique L. Den Boer, PY - 2013/10/03 Y2 - 2024/03/29 TI - Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells JF - Haematologica JA - haematol VL - 98 IS - 10 SE - Articles DO - 10.3324/haematol.2013.084434 UR - https://haematologica.org/article/view/6804 SP - 1539-1546 AB - This study investigated Polo-like kinase 1, a mitotic regulator often over-expressed in solid tumors and adult hematopoietic malignancies, as a potential new target in the treatment of pediatric acute lymphoblastic leukemia. Polo-like kinase 1 protein and Thr210 phosphorylation levels were higher in pediatric acute lymphoblastic leukemia (n=172) than in normal bone marrow mononuclear cells (n=10) (P