TY - JOUR AU - Eva Weingrill, AU - Albert Wölfler, AU - Dirk Strunk, AU - Werner Linkesch, AU - Heinz Sill, AU - Peter M. Liebmann, PY - 2007/09/01 Y2 - 2024/03/28 TI - Roscovitine in B-chronic lymphocytic leukemia cells: high apoptosis-inducing efficacy and synergism with alemtuzumab independent of the patients’ pretreatment status JF - Haematologica JA - haematol VL - 92 IS - 9 SE - Letters to the Editor DO - 10.3324/haematol.10680 UR - https://haematologica.org/article/view/4582 SP - 1286-1288 AB - Roscovitine induced apoptosis in isolated B-chronic lymphocytic leukemia cells of 25 patients of whom nine with relapsed and seven with fludarabine-refractory disease. It was synergistic with alemtuzumab and restored sensitivity to alemtuzumab in initially alemtuzumab-resistant samples. Observed roscovitine-induced up-regulation of CD52 surface expression may be one of the underlying mechanisms for this synergism. ER -