TY - JOUR AU - Wilma Pellegrini, AU - Giuliana Bresciani, AU - Anna De Zorzi, AU - Daniela Marocolo, AU - Marco Ungari, AU - Fabio Facchetti, PY - 2007/05/01 Y2 - 2024/03/28 TI - MMA monoclonal antibody is a superior anti-CD15 reagent for the diagnosis of classical Hodgkin’s lymphoma JF - Haematologica JA - haematol VL - 92 IS - 5 SE - Letters to the Editor DO - 10.3324/haematol.11002 UR - https://haematologica.org/article/view/4450 SP - 708-709 AB - CD15 is a useful immunohistochemical marker to identify Reed-Sternberg cells in classical Hodgkin’s lymphoma (HL) and to distinguish it from HD-like neoplasms, but data from the literature concerning its expression in HL are quite variable. Using immunohistochemistry we compared the reactivity of three different anti-CD15 clones (MMA, C3D1 and BY87) and found that anti-CD15 MMA clone is a superior reagent in identifying atypical cells, detecting more numerous cells in 28.2%, and being the only positive marker in 12.8% of cases. We conclude that it is advisable to include this reagent in diagnostic immunohistochemical panels. ER -