TY - JOUR AU - R Bataille, AU - G Jego, AU - N Robillard, AU - S Barille-Nion, AU - JL Harousseau, AU - P Moreau, AU - M Amiot, AU - C Pellat-Deceunynck, PY - 2006/09/01 Y2 - 2024/03/28 TI - The phenotype of normal, reactive and malignant plasma cells. Identification of "many and multiple myelomas" and of new targets for myeloma therapy JF - Haematologica JA - haematol VL - 91 IS - 9 SE - Articles DO - 10.3324/%x UR - https://haematologica.org/article/view/4150 SP - 1234-1240 AB - The aim of this review is to integrate non-exhaustive relevant data on the phenotype of human plasma cells (PC), including normal, reactive and malignant (multiple myeloma, MM) PC. This review focuses on (i) a universal marker of both normal and malignant plasma cells, CD138; (ii) markers related to malignancy i.e., CD19, CD27, CD28, and CD56; (iii) markers associated with signaling and severity of MM (CD45, CD221). Finally, this review presents data from normal PC up to human myeloma cell lines in order to: (i) define different entities of MM based on expression of CD19, CD20, CD27 and CD117; and (ii) identify new therapeutic targets. ER -