TY - JOUR AU - P Tsirigotis, AU - RO Bitan, AU - IB Resnick, AU - S Samuel, AU - A Ackerstein, AU - S Eladi, AU - B Gesundheit, AU - I Zilberman, AU - S Miron, AU - A Leubovic, AU - S Slavin, AU - MY Shapira, PY - 2006/06/01 Y2 - 2024/03/29 TI - A non-myeloablative conditioning regimen in allogeneic stem cell transplantation from related and unrelated donors in elderly patients JF - Haematologica JA - haematol VL - 91 IS - 6 SE - Comparative Studies DO - 10.3324/%x UR - https://haematologica.org/article/view/4019 SP - 852-855 AB - We describe our experience with the use of a single non-myeloablative preparative regimen in stem-cell transplantation (NST) in 37 heavily pretreated patients > or =55 years. The conditioning regimen consisted of fludarabine, low-dose busulfan, and antithymocyte globulin. Acute graft-versus-host disease (GVHD) grade III-IV and chronic GVHD developed in 15.6% and 44.4% of cases, respectively. With a median follow-up period of 22 (range 3-113) months, the 1-year overall survival and disease-free-survival were 55% and 53%, respectively, while the overall non-relapse mortality was 35%. In conclusion, reduced intensity stem cell transplantation is feasible and effective in patients > or =55 years. Age per se, should no longer be considered as a contra-indication to stem cell transplantation. ER -