TY - JOUR AU - M Eguchi-Ishimae, AU - M Eguchi, AU - E Ishii, AU - D Knight, AU - Y Sadakane, AU - K Isoyama, AU - H Yabe, AU - S Mizutani, AU - M Greaves, PY - 2005/11/01 Y2 - 2024/03/28 TI - The association of a distinctive allele of NAD(P)H:quinone oxidoreductase with pediatric acute lymphoblastic leukemias with MLL fusion genes in Japan JF - Haematologica JA - haematol VL - 90 IS - 11 SE - Comparative Studies DO - 10.3324/%x UR - https://haematologica.org/article/view/3714 SP - 1511-1515 AB - BACKGROUND AND OBJECTIVES: The enzyme NAD(P)H:quinone oxidoreductase (NQO1) detoxifies chemicals with quinone rings including benzene metabolites and flavonoids. Previous studies in Caucasian populations have provided evidence that a loss of function allele at nt 609 (C609T, Pro187Ser) is associated with increased risk of infant acute lymphoblastic leukemia (ALL) with MLL-AF4 fusion genes. DESIGN AND METHODS: We genotyped 103 infants (