TY - JOUR AU - N Carrere, AU - MA Belaud-Rotureau, AU - P Dubus, AU - M Parrens, AU - A de Mascarel, AU - JP Merlio, PY - 2005/06/01 Y2 - 2024/03/29 TI - The relative levels of cyclin D1a and D1b alternative transcripts in mantle cell lymphoma may depend more on sample origin than on CCND1 polymorphism JF - Haematologica JA - haematol VL - 90 IS - 6 SE - Letters to the Editor DO - 10.3324/%x UR - https://haematologica.org/article/view/3566 SP - 854-856 AB - The relative levels of cyclin D1 (CCND1) (a) and (b) transcripts were determined by real-time reverse transcription polymerase chain reaction (RT-PCR) and found to vary according to the tissue origin in both control and tumor samples. A five-fold overexpression of both isoforms was observed in 28/38 cases of mantle cell lymphoma (MCL) and of only one isoform in 10/38 MCL. No correlation was observed between expression of cyclin D1 isoforms and CCND1 genotype at position 870. ER -