TY - JOUR AU - A Hill, AU - MA Short, AU - C Varghese, AU - P Kusumakumary, AU - P Kumari, AU - GJ Morgan, PY - 2005/03/01 Y2 - 2024/03/28 TI - The t(12:21) is underrepresented in childhood B-lineage acute lymphoblastic leukemia in Kerala, Southern India JF - Haematologica JA - haematol VL - 90 IS - 3 SE - Letters to the Editor DO - 10.3324/%x UR - https://haematologica.org/article/view/3450 SP - 414-416 AB - t(12;21) (TEL/AML1) is the most common genetic event in childhood B-cell acute lymphoblastic leukemia (B-ALL) in Western countries. Samples from 42 children with ALL in Kerala were tested by reverse transcription polymerase chain reaction for TEL/AML1, t(1;19) and t(4;11). Only 2 out of 42 (4.8%) cases were positive for the TEL/AML1, and t(1;19) and t(4;11) were not detected. We conclude that the incidence of TEL/AML1 is lower in the Indian population. ER -