TY - JOUR AU - Bruno, Benedetto AU - Wäsch, Ralph AU - Engelhardt, Monika AU - Gay, Francesca AU - Giaccone, Luisa AU - D’Agostino, Mattia AU - Rodríguez-Lobato, Luis-Gerardo AU - Danhof, Sophia AU - Gagelmann, Nico AU - Kröger, Nicolaus AU - Popat, Rakesh AU - van de Donk, Niels W.C.J. AU - Terpos, Evangelos AU - Dimopoulos, Meletios A. AU - Sonneveld, Pieter AU - Einsele, Hermann AU - Boccadoro, Mario PY - 2021/08/01 Y2 - 2024/03/29 TI - European Myeloma Network perspective on CAR T-Cell therapies for multiple myeloma JF - Haematologica JA - haematol VL - 106 IS - 8 SE - Review Articles DO - 10.3324/haematol.2020.276402 UR - https://haematologica.org/article/view/haematol.2020.276402 SP - 2054-2065 AB - Chimeric antigen receptor (CAR) T cells (CAR-T) have dramatically changed the treatment landscape of B-cell malignancies, providing a potential cure for relapsed/refractory patients. Long-term responses in patients with acute lymphoblastic leukemia and non Hodgkin lymphomas have encouraged further development in myeloma. In particular, B-cell maturation antigen (BCMA)-targeted CAR-T have established very promising results in heavily pre-treated patients. Moreover, CAR-T targeting other antigens (i.e., SLAMF7 and CD44v6) are currently under investigation. However, none of these current autologous therapies have been approved, and despite high overall response rates across studies, main issues such as long-term outcome, toxicities, treatment resistance, and management of complications limit as yet their widespread use. Here, we critically review the most important pre-clinical and clinical findings, recent advances in CAR-T against myeloma, as well as discoveries in the biology of a still incurable disease, that, all together, will further improve safety and efficacy in relapsed/refractory patients, urgently in need of novel treatment options. ER -